BRD-A25170757_1-(4,5-bis(benzyloxy)-2-fluorophenyl)-2-(methylamino)ethanol KLK-33_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

66 genes differentially expressed following the BRD-A25170757_1-(4,5-bis(benzyloxy)-2-fluorophenyl)-2-(methylamino)ethanol KLK-33_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACP5 acid phosphatase 5, tartrate resistant
AKAP12 A kinase (PRKA) anchor protein 12
ALDOC aldolase C, fructose-bisphosphate
AQP3 aquaporin 3 (Gill blood group)
CLGN calmegin
COTL1 coactosin-like F-actin binding protein 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYSL3 dihydropyrimidinase-like 3
DUSP4 dual specificity phosphatase 4
EDNRA endothelin receptor type A
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FADS1 fatty acid desaturase 1
FCGBP Fc fragment of IgG binding protein
FOLR1 folate receptor 1 (adult)
GAA glucosidase, alpha; acid
GSTM3 glutathione S-transferase mu 3 (brain)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IFITM1 interferon induced transmembrane protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL7R interleukin 7 receptor
IRS2 insulin receptor substrate 2
LDLR low density lipoprotein receptor
LY96 lymphocyte antigen 96
MSMO1 methylsterol monooxygenase 1
MVP major vault protein
NEFH neurofilament, heavy polypeptide
NLGN4X neuroligin 4, X-linked
PIP prolactin-induced protein
PLAT plasminogen activator, tissue
QPRT quinolinate phosphoribosyltransferase
RABAC1 Rab acceptor 1 (prenylated)
RPL37A ribosomal protein L37a
S100A6 S100 calcium binding protein A6
S100P S100 calcium binding protein P
SFN stratifin
SPTBN1 spectrin, beta, non-erythrocytic 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SYT1 synaptotagmin I
TM4SF1 transmembrane 4 L six family member 1
TSPAN31 tetraspanin 31
TSPAN8 tetraspanin 8

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CCND2 cyclin D2
EIF5 eukaryotic translation initiation factor 5
EIF5B eukaryotic translation initiation factor 5B
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
IGFBP5 insulin-like growth factor binding protein 5
IL13RA1 interleukin 13 receptor, alpha 1
ISOC1 isochorismatase domain containing 1
LOC100505650 uncharacterized LOC100505650
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MELK maternal embryonic leucine zipper kinase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
POSTN periostin, osteoblast specific factor
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
SH3YL1 SH3 and SYLF domain containing 1
SRSF6 serine/arginine-rich splicing factor 6
TCF4 transcription factor 4
TOP2A topoisomerase (DNA) II alpha 170kDa