BRD-A25170757_1-(4,5-bis(benzyloxy)-2-fluorophenyl)-2-(methylamino)ethanol KLK-33_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

138 genes differentially expressed following the BRD-A25170757_1-(4,5-bis(benzyloxy)-2-fluorophenyl)-2-(methylamino)ethanol KLK-33_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AP2M1 adaptor-related protein complex 2, mu 1 subunit
APOD apolipoprotein D
ARMCX1 armadillo repeat containing, X-linked 1
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
C1ORF115 chromosome 1 open reading frame 115
CD163 CD163 molecule
CD36 CD36 molecule (thrombospondin receptor)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRDL1 chordin-like 1
CLGN calmegin
CLIC4 chloride intracellular channel 4
CLU clusterin
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
FAM131A family with sequence similarity 131, member A
FAM134A family with sequence similarity 134, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FHL1 four and a half LIM domains 1
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
GPX4 glutathione peroxidase 4
GRB10 growth factor receptor-bound protein 10
GRIA2 glutamate receptor, ionotropic, AMPA 2
H1F0 H1 histone family, member 0
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
KLHL24 kelch-like family member 24
LGALS1 lectin, galactoside-binding, soluble, 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LPL lipoprotein lipase
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAP7 microtubule-associated protein 7
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha)
MSMO1 methylsterol monooxygenase 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1X metallothionein 1X
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPTX2 neuronal pentraxin II
NRCAM neuronal cell adhesion molecule
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1 proprotein convertase subtilisin/kexin type 1
PDZD2 PDZ domain containing 2
PECAM1 platelet/endothelial cell adhesion molecule 1
PLIN1 perilipin 1
PPL periplakin
PRUNE2 prune homolog 2 (Drosophila)
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
RBP4 retinol binding protein 4, plasma
RND3 Rho family GTPase 3
RTN1 reticulon 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SPARCL1 SPARC-like 1 (hevin)
SQLE squalene epoxidase
SQSTM1 sequestosome 1
TMEM176B transmembrane protein 176B
TMSB15A thymosin beta 15a
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VWF von Willebrand factor
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZBTB16 zinc finger and BTB domain containing 16

decreased expression

Symbol Name
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA3 annexin A3
ARG1 arginase 1
CCND1 cyclin D1
CD24 CD24 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
COCH cochlin
COL11A1 collagen, type XI, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
CSTA cystatin A (stefin A)
DEFA4 defensin, alpha 4, corticostatin
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DUSP6 dual specificity phosphatase 6
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPHA3 EPH receptor A3
FN1 fibronectin 1
GCH1 GTP cyclohydrolase 1
GLS glutaminase
HDDC2 HD domain containing 2
HSPA2 heat shock 70kDa protein 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1R2 interleukin 1 receptor, type II
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KLK11 kallikrein-related peptidase 11
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTF lactotransferrin
LY6D lymphocyte antigen 6 complex, locus D
MALL mal, T-cell differentiation protein-like
MMP8 matrix metallopeptidase 8
MSH6 mutS homolog 6
MXRA5 matrix-remodelling associated 5
NXN nucleoredoxin
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PRKCA protein kinase C, alpha
RCAN1 regulator of calcineurin 1
RGS10 regulator of G-protein signaling 10
RPIA ribose 5-phosphate isomerase A
S100A7 S100 calcium binding protein A7
SLPI secretory leukocyte peptidase inhibitor
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM45A transmembrane protein 45A
TPM1 tropomyosin 1 (alpha)
UBE2N ubiquitin-conjugating enzyme E2N
ZNF586 zinc finger protein 586