BRD-A25088322_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-A25088322_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
ADORA2B adenosine A2b receptor
AK4 adenylate kinase 4
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
CBR3 carbonyl reductase 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CNN3 calponin 3, acidic
COMP cartilage oligomeric matrix protein
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
EGR1 early growth response 1
EREG epiregulin
FABP7 fatty acid binding protein 7, brain
FOSL1 FOS-like antigen 1
GCLM glutamate-cysteine ligase, modifier subunit
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFRD1 interferon-related developmental regulator 1
IL1R2 interleukin 1 receptor, type II
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KDM5A lysine (K)-specific demethylase 5A
LOX lysyl oxidase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP7 matrix metallopeptidase 7
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1M metallothionein 1M
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NQO2 NAD(P)H dehydrogenase, quinone 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4DIP phosphodiesterase 4D interacting protein
PIR pirin (iron-binding nuclear protein)
PLIN2 perilipin 2
POPDC3 popeye domain containing 3
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
RND3 Rho family GTPase 3
RNF167 ring finger protein 167
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFN stratifin
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRY2 sprouty homolog 2 (Drosophila)
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
STC2 stanniocalcin 2
TGIF1 TGFB-induced factor homeobox 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB1 tribbles pseudokinase 1
TXN thioredoxin
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BASP1 brain abundant, membrane attached signal protein 1
BCHE butyrylcholinesterase
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNE2 cyclin E2
CD93 CD93 molecule
CPNE3 copine III
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DTX4 deltex 4, E3 ubiquitin ligase
FHL1 four and a half LIM domains 1
GATA2 GATA binding protein 2
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCTD12 potassium channel tetramerization domain containing 12
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM3 minichromosome maintenance complex component 3
MLEC malectin
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR2F1 nuclear receptor subfamily 2, group F, member 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PEG10 paternally expressed 10
PRKCD protein kinase C, delta
PRSS21 protease, serine, 21 (testisin)
PTGIS prostaglandin I2 (prostacyclin) synthase
RGS5 regulator of G-protein signaling 5
SDC1 syndecan 1
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TARP TCR gamma alternate reading frame protein
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
VNN1 vanin 1