BRD-A25004090_erastin_PC3_24.0_h_4.8_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

46 genes differentially expressed following the BRD-A25004090_erastin_PC3_24.0_h_4.8_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AARS alanyl-tRNA synthetase
ADM adrenomedullin
AKR1C3 aldo-keto reductase family 1, member C3
AQP9 aquaporin 9
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
CBS cystathionine-beta-synthase
CTH cystathionine gamma-lyase
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPRS glutamyl-prolyl-tRNA synthetase
GARS glycyl-tRNA synthetase
GSTA1 glutathione S-transferase alpha 1
HMOX1 heme oxygenase 1
MARS methionyl-tRNA synthetase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NTS neurotensin
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAT1 phosphoserine aminotransferase 1
REG1A regenerating islet-derived 1 alpha
RGS4 regulator of G-protein signaling 4
SARS seryl-tRNA synthetase
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
STC2 stanniocalcin 2
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
AHNAK2 AHNAK nucleoprotein 2
CCL5 chemokine (C-C motif) ligand 5
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
GAS1 growth arrest-specific 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
NFIB nuclear factor I/B
SRPX sushi-repeat containing protein, X-linked
SYNM synemin, intermediate filament protein
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1