BRD-A24643465_homoharringtonine_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

282 genes differentially expressed following the BRD-A24643465_homoharringtonine_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
AMOTL2 angiomotin like 2
ANXA1 annexin A1
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
ARHGAP15 Rho GTPase activating protein 15
ARHGAP29 Rho GTPase activating protein 29
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
BHLHE40 basic helix-loop-helix family, member e40
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C7 complement component 7
CADM1 cell adhesion molecule 1
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN1 claudin 1
CLK4 CDC-like kinase 4
COL14A1 collagen, type XIV, alpha 1
CTGF connective tissue growth factor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
CYTH1 cytohesin 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DLX2 distal-less homeobox 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP14 dual specificity phosphatase 14
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR2 early growth response 2
EMP1 epithelial membrane protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
EREG epiregulin
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FILIP1L filamin A interacting protein 1-like
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
G0S2 G0/G1 switch 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GATA6 GATA binding protein 6
GEM GTP binding protein overexpressed in skeletal muscle
GSTM3 glutathione S-transferase mu 3 (brain)
H2BFS H2B histone family, member S (pseudogene)
H3F3B H3 histone, family 3B (H3.3B)
HBEGF heparin-binding EGF-like growth factor
HDAC9 histone deacetylase 9
HEG1 heart development protein with EGF-like domains 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BI histone cluster 1, H2bi
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IGF1R insulin-like growth factor 1 receptor
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL1B interleukin 1, beta
IL6 interleukin 6
IRF1 interferon regulatory factor 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT7 keratin 7, type II
KYNU kynureninase
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LIMCH1 LIM and calponin homology domains 1
LIPG lipase, endothelial
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MCL1 myeloid cell leukemia 1
MMP7 matrix metallopeptidase 7
MOK MOK protein kinase
MPO myeloperoxidase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRG1 neuregulin 1
NRIP1 nuclear receptor interacting protein 1
ODC1 ornithine decarboxylase 1
PDE4D phosphodiesterase 4D, cAMP-specific
PDHX pyruvate dehydrogenase complex, component X
PDLIM5 PDZ and LIM domain 5
PEG3 paternally expressed 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAU plasminogen activator, urokinase
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSPC1 paraspeckle component 1
PTBP2 polypyrimidine tract binding protein 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RBKS ribokinase
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RND1 Rho family GTPase 1
RRAD Ras-related associated with diabetes
RSRC2 arginine/serine-rich coiled-coil 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SELE selectin E
SIK1 salt-inducible kinase 1
SLC16A6 solute carrier family 16, member 6
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD3 SMAD family member 3
SOCS3 suppressor of cytokine signaling 3
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
SRSF7 serine/arginine-rich splicing factor 7
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBC1D31 TBC1 domain family, member 31
TBX3 T-box 3
TFF1 trefoil factor 1
TGIF1 TGFB-induced factor homeobox 1
THBS1 thrombospondin 1
THUMPD2 THUMP domain containing 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIK TRAF2 and NCK interacting kinase
TP53 tumor protein p53
TRIM16 tripartite motif containing 16
TSC22D1 TSC22 domain family, member 1
TSC22D2 TSC22 domain family, member 2
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
VCAM1 vascular cell adhesion molecule 1
VNN1 vanin 1
VWF von Willebrand factor
WSB1 WD repeat and SOCS box containing 1
YPEL5 yippee-like 5 (Drosophila)
ZBED2 zinc finger, BED-type containing 2
ZC3H12A zinc finger CCCH-type containing 12A
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
APLP2 amyloid beta (A4) precursor-like protein 2
AQP3 aquaporin 3 (Gill blood group)
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCHE butyrylcholinesterase
BLCAP bladder cancer associated protein
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C1QB complement component 1, q subcomponent, B chain
CA12 carbonic anhydrase XII
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALU calumenin
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CLCA4 chloride channel accessory 4
COL3A1 collagen, type III, alpha 1
CSTA cystatin A (stefin A)
CTSH cathepsin H
CTSL cathepsin L
DPYSL2 dihydropyrimidinase-like 2
DUSP7 dual specificity phosphatase 7
ECI2 enoyl-CoA delta isomerase 2
EMP2 epithelial membrane protein 2
EPRS glutamyl-prolyl-tRNA synthetase
ESRP1 epithelial splicing regulatory protein 1
FAR2 fatty acyl CoA reductase 2
FASN fatty acid synthase
FKBP1B FK506 binding protein 1B, 12.6 kDa
GAL galanin/GMAP prepropeptide
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GDE1 glycerophosphodiester phosphodiesterase 1
GLUL glutamate-ammonia ligase
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GRN granulin
HOXB7 homeobox B7
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KRT1 keratin 1, type II
LIPA lipase A, lysosomal acid, cholesterol esterase
MAN1A1 mannosidase, alpha, class 1A, member 1
MLEC malectin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NMU neuromedin U
NRIP3 nuclear receptor interacting protein 3
OAT ornithine aminotransferase
OLFML3 olfactomedin-like 3
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PCOLCE procollagen C-endopeptidase enhancer
PCOLCE2 procollagen C-endopeptidase enhancer 2
PGK1 phosphoglycerate kinase 1
PI3 peptidase inhibitor 3, skin-derived
PIR pirin (iron-binding nuclear protein)
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCD protein kinase C, delta
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PTEN phosphatase and tensin homolog
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASET2 ribonuclease T2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SFN stratifin
SNX6 sorting nexin 6
TM9SF2 transmembrane 9 superfamily member 2
TMEM45A transmembrane protein 45A
TMEM97 transmembrane protein 97
TSPAN13 tetraspanin 13
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)