BRD-A24643465_homoharringtonine_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

197 genes differentially expressed following the BRD-A24643465_homoharringtonine_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ANKRD12 ankyrin repeat domain 12
ANKRD28 ankyrin repeat domain 28
APOLD1 apolipoprotein L domain containing 1
ARID4B AT rich interactive domain 4B (RBP1-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
BIRC2 baculoviral IAP repeat containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CD24 CD24 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CHIC2 cysteine-rich hydrophobic domain 2
CLU clusterin
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSRP2 cysteine and glycine-rich protein 2
CYLD cylindromatosis (turban tumor syndrome)
CYR61 cysteine-rich, angiogenic inducer, 61
DHRS2 dehydrogenase/reductase (SDR family) member 2
DUSP1 dual specificity phosphatase 1
EFNA1 ephrin-A1
EMP1 epithelial membrane protein 1
FILIP1L filamin A interacting protein 1-like
FLRT2 fibronectin leucine rich transmembrane protein 2
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GEM GTP binding protein overexpressed in skeletal muscle
GSTM3 glutathione S-transferase mu 3 (brain)
H1F0 H1 histone family, member 0
H2BFS H2B histone family, member S (pseudogene)
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BI histone cluster 1, H2bi
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER5 immediate early response 5
IGL immunoglobulin lambda locus
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL6 interleukin 6
IL7R interleukin 7 receptor
JMJD1C jumonji domain containing 1C
JUN jun proto-oncogene
JUND jun D proto-oncogene
KLF11 Kruppel-like factor 11
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAL mal, T-cell differentiation protein
MLF1 myeloid leukemia factor 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRG1 neuregulin 1
PDE1A phosphodiesterase 1A, calmodulin-dependent
PDLIM5 PDZ and LIM domain 5
PEG3 paternally expressed 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RSRC2 arginine/serine-rich coiled-coil 2
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SFRP4 secreted frizzled-related protein 4
SIRT1 sirtuin 1
SLC16A6 solute carrier family 16, member 6
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SOCS2 suppressor of cytokine signaling 2
SRSF7 serine/arginine-rich splicing factor 7
SWAP70 SWAP switching B-cell complex 70kDa subunit
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TEX10 testis expressed 10
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOX3 TOX high mobility group box family member 3
TP53 tumor protein p53
TP53BP2 tumor protein p53 binding protein 2
TRBC1 T cell receptor beta constant 1
TXNIP thioredoxin interacting protein
ZBTB20 zinc finger and BTB domain containing 20
ZFP36 ZFP36 ring finger protein
ZNF274 zinc finger protein 274
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5 arachidonate 5-lipoxygenase
AMD1 adenosylmethionine decarboxylase 1
APLP2 amyloid beta (A4) precursor-like protein 2
AQP3 aquaporin 3 (Gill blood group)
B3GNT1
CA12 carbonic anhydrase XII
CALU calumenin
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CDK1 cyclin-dependent kinase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL8A2 collagen, type VIII, alpha 2
CP ceruloplasmin (ferroxidase)
CRABP2 cellular retinoic acid binding protein 2
CSK c-src tyrosine kinase
CSTA cystatin A (stefin A)
CTSB cathepsin B
CTSH cathepsin H
DKK1 dickkopf WNT signaling pathway inhibitor 1
DOK4 docking protein 4
DPYSL2 dihydropyrimidinase-like 2
DTX4 deltex 4, E3 ubiquitin ligase
DUSP4 dual specificity phosphatase 4
EFS embryonal Fyn-associated substrate
EMP2 epithelial membrane protein 2
ENDOD1 endonuclease domain containing 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS1 fatty acid desaturase 1
FAM57A family with sequence similarity 57, member A
FASN fatty acid synthase
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GRN granulin
HMGA2 high mobility group AT-hook 2
HOXB2 homeobox B2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
IRAK1 interleukin-1 receptor-associated kinase 1
KANK2 KN motif and ankyrin repeat domains 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0101 KIAA0101
KIAA0125 KIAA0125
KIF5B kinesin family member 5B
LIPA lipase A, lysosomal acid, cholesterol esterase
LOXL1 lysyl oxidase-like 1
LRP10 low density lipoprotein receptor-related protein 10
LY6E lymphocyte antigen 6 complex, locus E
MCAM melanoma cell adhesion molecule
MCM6 minichromosome maintenance complex component 6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MME membrane metallo-endopeptidase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NES nestin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NT5DC2 5'-nucleotidase domain containing 2
OAT ornithine aminotransferase
OXTR oxytocin receptor
PCNA proliferating cell nuclear antigen
PHGDH phosphoglycerate dehydrogenase
PKM pyruvate kinase, muscle
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PRKCD protein kinase C, delta
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RPA1 replication protein A1, 70kDa
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SEPP1 selenoprotein P, plasma, 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC46A3 solute carrier family 46, member 3
SORBS3 sorbin and SH3 domain containing 3
SPON1 spondin 1, extracellular matrix protein
STARD7 StAR-related lipid transfer (START) domain containing 7
TBC1D16 TBC1 domain family, member 16
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM97 transmembrane protein 97
TPD52L1 tumor protein D52-like 1
TSPAN13 tetraspanin 13
TSPAN3 tetraspanin 3
TUBG1 tubulin, gamma 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
XPOT exportin, tRNA