BRD-A24643465_homoharringtonine_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

131 genes differentially expressed following the BRD-A24643465_homoharringtonine_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM28 ADAM metallopeptidase domain 28
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
BCL3 B-cell CLL/lymphoma 3
BEX1 brain expressed, X-linked 1
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
C4BPA complement component 4 binding protein, alpha
C8ORF4 chromosome 8 open reading frame 4
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CES1 carboxylesterase 1
CHI3L2 chitinase 3-like 2
COL9A3 collagen, type IX, alpha 3
CYR61 cysteine-rich, angiogenic inducer, 61
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
FBLN1 fibulin 1
FGG fibrinogen gamma chain
GADD45B growth arrest and DNA-damage-inducible, beta
GPC3 glypican 3
GSTM3 glutathione S-transferase mu 3 (brain)
H2BFS H2B histone family, member S (pseudogene)
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HP haptoglobin
ICAM1 intercellular adhesion molecule 1
IGFBP4 insulin-like growth factor binding protein 4
IL6ST interleukin 6 signal transducer
IRF1 interferon regulatory factor 1
JUN jun proto-oncogene
KLF10 Kruppel-like factor 10
LTF lactotransferrin
LYST lysosomal trafficking regulator
MAGEA3 melanoma antigen family A3
MAL mal, T-cell differentiation protein
MUC5B mucin 5B, oligomeric mucus/gel-forming
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRN1 neuritin 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRAME preferentially expressed antigen in melanoma
PRKCB protein kinase C, beta
PURA purine-rich element binding protein A
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOB ras homolog family member B
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SFTPA2 surfactant protein A2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SMYD3 SET and MYND domain containing 3
STX18 syntaxin 18
SYNGR3 synaptogyrin 3
TFF3 trefoil factor 3 (intestinal)
TKTL1 transketolase-like 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRBC1 T cell receptor beta constant 1
TSC22D1 TSC22 domain family, member 1
TXNIP thioredoxin interacting protein
WNT5A wingless-type MMTV integration site family, member 5A
ZBTB18 zinc finger and BTB domain containing 18
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADI1 acireductone dioxygenase 1
ADIRF adipogenesis regulatory factor
ANXA2 annexin A2
AQP3 aquaporin 3 (Gill blood group)
ATF5 activating transcription factor 5
B3GNT1
C6ORF62 chromosome 6 open reading frame 62
CANT1 calcium activated nucleotidase 1
CDC20 cell division cycle 20
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
DHCR7 7-dehydrocholesterol reductase
DPYSL2 dihydropyrimidinase-like 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FAM57A family with sequence similarity 57, member A
FERMT1 fermitin family member 1
FHL1 four and a half LIM domains 1
GATA3 GATA binding protein 3
GNPDA1 glucosamine-6-phosphate deaminase 1
GREM1 gremlin 1, DAN family BMP antagonist
H2AFX H2A histone family, member X
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA1A heat shock 70kDa protein 1A
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
KCTD12 potassium channel tetramerization domain containing 12
KIF14 kinesin family member 14
KRT6B keratin 6B, type II
LHX2 LIM homeobox 2
METTL9 methyltransferase like 9
MSMO1 methylsterol monooxygenase 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
OLFM4 olfactomedin 4
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCNA proliferating cell nuclear antigen
PDGFD platelet derived growth factor D
PI3 peptidase inhibitor 3, skin-derived
POSTN periostin, osteoblast specific factor
PXDN peroxidasin
RPL37A ribosomal protein L37a
SCAND1 SCAN domain containing 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TMSB15A thymosin beta 15a
TUBB6 tubulin, beta 6 class V
TYMS thymidylate synthetase
ZMYM2 zinc finger, MYM-type 2