BRD-A24643465_homoharringtonine_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

252 genes differentially expressed following the BRD-A24643465_homoharringtonine_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
AKAP12 A kinase (PRKA) anchor protein 12
ALCAM activated leukocyte cell adhesion molecule
AREG amphiregulin
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AZU1 azurocidin 1
BCL3 B-cell CLL/lymphoma 3
BEX1 brain expressed, X-linked 1
BHLHE40 basic helix-loop-helix family, member e40
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BTG2 BTG family, member 2
C6ORF48 chromosome 6 open reading frame 48
C7 complement component 7
C8ORF4 chromosome 8 open reading frame 4
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CD83 CD83 molecule
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CLK4 CDC-like kinase 4
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
CTGF connective tissue growth factor
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DLK1 delta-like 1 homolog (Drosophila)
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ELANE elastase, neutrophil expressed
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F3 coagulation factor III (thromboplastin, tissue factor)
FLRT3 fibronectin leucine rich transmembrane protein 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
GPATCH8 G patch domain containing 8
GSTM3 glutathione S-transferase mu 3 (brain)
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HDAC9 histone deacetylase 9
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BK histone cluster 1, H2bk
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
ICAM1 intercellular adhesion molecule 1
ICAM2 intercellular adhesion molecule 2
IER2 immediate early response 2
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IGFBP7 insulin-like growth factor binding protein 7
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL1A interleukin 1, alpha
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
ING3 inhibitor of growth family, member 3
INTS6 integrator complex subunit 6
IRF1 interferon regulatory factor 1
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KDM5B lysine (K)-specific demethylase 5B
KDM6B lysine (K)-specific demethylase 6B
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
LIPG lipase, endothelial
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MCL1 myeloid cell leukemia 1
MIR22HG MIR22 host gene
MSLN mesothelin
NDNF neuron-derived neurotrophic factor
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PDE4B phosphodiesterase 4B, cAMP-specific
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFTN1 raftlin, lipid raft linker 1
RGS5 regulator of G-protein signaling 5
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RND1 Rho family GTPase 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SELE selectin E
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SOBP sine oculis binding protein homolog (Drosophila)
SOCS3 suppressor of cytokine signaling 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STAR steroidogenic acute regulatory protein
SYNGR3 synaptogyrin 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TENM1 teneurin transmembrane protein 1
THBS1 thrombospondin 1
TICAM1 toll-like receptor adaptor molecule 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TMEM176B transmembrane protein 176B
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIK TRAF2 and NCK interacting kinase
TNIP1 TNFAIP3 interacting protein 1
TRAF1 TNF receptor-associated factor 1
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
VCAM1 vascular cell adhesion molecule 1
WSB1 WD repeat and SOCS box containing 1
ZBED2 zinc finger, BED-type containing 2
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZHX2 zinc fingers and homeoboxes 2
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ATG3 autophagy related 3
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
B3GNT1
BCHE butyrylcholinesterase
C14ORF132 chromosome 14 open reading frame 132
CA12 carbonic anhydrase XII
CACYBP calcyclin binding protein
CALU calumenin
CCDC109B coiled-coil domain containing 109B
CCNA2 cyclin A2
CD200 CD200 molecule
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CKLF chemokine-like factor
COL6A1 collagen, type VI, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CTSZ cathepsin Z
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
ENO2 enolase 2 (gamma, neuronal)
FAM57A family with sequence similarity 57, member A
FBLN1 fibulin 1
FKBP1A FK506 binding protein 1A, 12kDa
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GREM1 gremlin 1, DAN family BMP antagonist
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIAA0100 KIAA0100
LBR lamin B receptor
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LY6D lymphocyte antigen 6 complex, locus D
MAT2A methionine adenosyltransferase II, alpha
MLPH melanophilin
MMP12 matrix metallopeptidase 12
MPZL1 myelin protein zero-like 1
NARF nuclear prelamin A recognition factor
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
PERP PERP, TP53 apoptosis effector
PGK1 phosphoglycerate kinase 1
PI3 peptidase inhibitor 3, skin-derived
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PIR pirin (iron-binding nuclear protein)
PROM1 prominin 1
RAP2A RAP2A, member of RAS oncogene family
RNASET2 ribonuclease T2
S100A7 S100 calcium binding protein A7
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC1 syndecan 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPHS1 selenophosphate synthetase 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPP1 secreted phosphoprotein 1
STARD7 StAR-related lipid transfer (START) domain containing 7
STK24 serine/threonine kinase 24
TBC1D16 TBC1 domain family, member 16
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFDP1 transcription factor Dp-1
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM243 transmembrane protein 243, mitochondrial
TMEM97 transmembrane protein 97
TMPO thymopoietin
TPD52L1 tumor protein D52-like 1
TSKU tsukushi, small leucine rich proteoglycan
TSPAN13 tetraspanin 13
TSPAN3 tetraspanin 3
TUBB tubulin, beta class I
VANGL1 VANGL planar cell polarity protein 1