BRD-A24643465_homoharringtonine_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-A24643465_homoharringtonine_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARHGAP29 Rho GTPase activating protein 29
ATF3 activating transcription factor 3
BTG2 BTG family, member 2
CADM1 cell adhesion molecule 1
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCL2 chemokine (C-C motif) ligand 2
CCNL1 cyclin L1
CD24 CD24 molecule
CLU clusterin
DHRS2 dehydrogenase/reductase (SDR family) member 2
DUSP5 dual specificity phosphatase 5
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EZR ezrin
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRY furry homolog (Drosophila)
GADD45B growth arrest and DNA-damage-inducible, beta
GSE1 Gse1 coiled-coil protein
HIST1H1C histone cluster 1, H1c
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IER2 immediate early response 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM5B lysine (K)-specific demethylase 5B
KLF6 Kruppel-like factor 6
KLK6 kallikrein-related peptidase 6
KRT15 keratin 15, type I
KRT19 keratin 19, type I
LIPG lipase, endothelial
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MPO myeloperoxidase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PEG3 paternally expressed 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRSS2 protease, serine, 2 (trypsin 2)
PTBP2 polypyrimidine tract binding protein 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOB ras homolog family member B
SOX9 SRY (sex determining region Y)-box 9
SSBP2 single-stranded DNA binding protein 2
STAR steroidogenic acute regulatory protein
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TUFT1 tuftelin 1
WEE1 WEE1 G2 checkpoint kinase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
B3GNT1
C1QB complement component 1, q subcomponent, B chain
CCND1 cyclin D1
CD59 CD59 molecule, complement regulatory protein
CDK4 cyclin-dependent kinase 4
CNPY2 canopy FGF signaling regulator 2
CSRP2 cysteine and glycine-rich protein 2
CTSH cathepsin H
CTSL cathepsin L
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCK deoxycytidine kinase
DLD dihydrolipoamide dehydrogenase
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ESD esterase D
FAM57A family with sequence similarity 57, member A
FEN1 flap structure-specific endonuclease 1
FSTL1 follistatin-like 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GNG10 guanine nucleotide binding protein (G protein), gamma 10
GNS glucosamine (N-acetyl)-6-sulfatase
GOLM1 golgi membrane protein 1
GOLT1B golgi transport 1B
GSTP1 glutathione S-transferase pi 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGA2 high mobility group AT-hook 2
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IDO1 indoleamine 2,3-dioxygenase 1
IFITM2 interferon induced transmembrane protein 2
ITGB1BP1 integrin beta 1 binding protein 1
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KIF20A kinesin family member 20A
LAPTM4B lysosomal protein transmembrane 4 beta
LYPLA1 lysophospholipase I
METTL9 methyltransferase like 9
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MTDH metadherin
NANS N-acetylneuraminic acid synthase
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NMU neuromedin U
NPC2 Niemann-Pick disease, type C2
NUP62 nucleoporin 62kDa
OSBPL8 oxysterol binding protein-like 8
PEG10 paternally expressed 10
PGAM1 phosphoglycerate mutase 1 (brain)
PRDX4 peroxiredoxin 4
PTDSS1 phosphatidylserine synthase 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RECQL RecQ helicase-like
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPA1 replication protein A1, 70kDa
RPIA ribose 5-phosphate isomerase A
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TBC1D16 TBC1 domain family, member 16
TBC1D4 TBC1 domain family, member 4
TM9SF2 transmembrane 9 superfamily member 2
TMEM97 transmembrane protein 97
TRIM14 tripartite motif containing 14
TRIP6 thyroid hormone receptor interactor 6
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UQCRB ubiquinol-cytochrome c reductase binding protein
VCAN versican
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
WSB2 WD repeat and SOCS box containing 2