BRD-A24543851_nornicotine_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

97 genes differentially expressed following the BRD-A24543851_nornicotine_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANGPT2 angiopoietin 2
AUTS2 autism susceptibility candidate 2
BAX BCL2-associated X protein
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CALML3 calmodulin-like 3
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CORO1A coronin, actin binding protein, 1A
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL11 chemokine (C-X-C motif) ligand 11
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
FXYD6 FXYD domain containing ion transport regulator 6
GNLY granulysin
GPM6B glycoprotein M6B
GPRC5B G protein-coupled receptor, class C, group 5, member B
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGKC immunoglobulin kappa constant
IQGAP1 IQ motif containing GTPase activating protein 1
JAM2 junctional adhesion molecule 2
JCHAIN joining chain of multimeric IgA and IgM
LAPTM5 lysosomal protein transmembrane 5
LRRC17 leucine rich repeat containing 17
MECOM MDS1 and EVI1 complex locus
MYL9 myosin, light chain 9, regulatory
NRCAM neuronal cell adhesion molecule
PCCB propionyl CoA carboxylase, beta polypeptide
PDZD2 PDZ domain containing 2
PEG10 paternally expressed 10
PLAU plasminogen activator, urokinase
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PODXL podocalyxin-like
PTN pleiotrophin
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RFTN1 raftlin, lipid raft linker 1
RPS5 ribosomal protein S5
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX7 sorting nexin 7
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TGFB3 transforming growth factor, beta 3
TMEM176B transmembrane protein 176B
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
ZIC1 Zic family member 1
ZNF589 zinc finger protein 589
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AHR aryl hydrocarbon receptor
AQP3 aquaporin 3 (Gill blood group)
CLU clusterin
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DAPK1 death-associated protein kinase 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
ELF1 E74-like factor 1 (ets domain transcription factor)
EVL Enah/Vasp-like
F5 coagulation factor V (proaccelerin, labile factor)
FGF13 fibroblast growth factor 13
FGFR4 fibroblast growth factor receptor 4
FOLR1 folate receptor 1 (adult)
GTPBP8 GTP-binding protein 8 (putative)
HOXC10 homeobox C10
HOXC6 homeobox C6
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IL6ST interleukin 6 signal transducer
KRT7 keratin 7, type II
LEF1 lymphoid enhancer-binding factor 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LY6E lymphocyte antigen 6 complex, locus E
MAGEA3 melanoma antigen family A3
OSBPL8 oxysterol binding protein-like 8
PHACTR2 phosphatase and actin regulator 2
PLAGL1 pleiomorphic adenoma gene-like 1
PRAME preferentially expressed antigen in melanoma
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STOM stomatin
SVIL supervillin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEX10 testis expressed 10
TRAPPC3 trafficking protein particle complex 3
WWP1 WW domain containing E3 ubiquitin protein ligase 1