BRD-A24396574_celastrol_SKBR3_3_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

56 genes differentially expressed following the BRD-A24396574_celastrol_SKBR3_3_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH3 cadherin 3, type 1, P-cadherin (placental)
COL9A3 collagen, type IX, alpha 3
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP2 dual specificity phosphatase 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPCAM epithelial cell adhesion molecule
HCAR3 hydroxycarboxylic acid receptor 3
HMOX1 heme oxygenase 1
IL1R2 interleukin 1 receptor, type II
MMP12 matrix metallopeptidase 12
MYO6 myosin VI
NOTCH1 notch 1
OLFM1 olfactomedin 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
RPS4Y1 ribosomal protein S4, Y-linked 1
RXRA retinoid X receptor, alpha
TFF3 trefoil factor 3 (intestinal)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
AHR aryl hydrocarbon receptor
APOA1 apolipoprotein A-I
ATM ATM serine/threonine kinase
CCL2 chemokine (C-C motif) ligand 2
CDC25B cell division cycle 25B
CDKN2A cyclin-dependent kinase inhibitor 2A
COG7 component of oligomeric golgi complex 7
CPE carboxypeptidase E
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
EPHA3 EPH receptor A3
GUSBP3 glucuronidase, beta pseudogene 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IKZF1 IKAROS family zinc finger 1 (Ikaros)
LCN2 lipocalin 2
LGALS1 lectin, galactoside-binding, soluble, 1
MSMO1 methylsterol monooxygenase 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PEG10 paternally expressed 10
PNMA2 paraneoplastic Ma antigen 2
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
RNASE6 ribonuclease, RNase A family, k6
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SGCE sarcoglycan, epsilon
STAT1 signal transducer and activator of transcription 1, 91kDa
TIMP1 TIMP metallopeptidase inhibitor 1