BRD-A24396574_celastrol_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

213 genes differentially expressed following the BRD-A24396574_celastrol_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKAP13 A kinase (PRKA) anchor protein 13
ANKRD10 ankyrin repeat domain 10
ANKRD12 ankyrin repeat domain 12
ARID4B AT rich interactive domain 4B (RBP1-like)
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ATF3 activating transcription factor 3
AVPI1 arginine vasopressin-induced 1
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BEX1 brain expressed, X-linked 1
BHLHE40 basic helix-loop-helix family, member e40
BTG1 B-cell translocation gene 1, anti-proliferative
CADM1 cell adhesion molecule 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2AIP CDKN2A interacting protein
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHD1 chromodomain helicase DNA binding protein 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COL9A3 collagen, type IX, alpha 3
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
DACH1 dachshund family transcription factor 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DLC1 DLC1 Rho GTPase activating protein
DLX2 distal-less homeobox 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
ELL2 elongation factor, RNA polymerase II, 2
FAM46A family with sequence similarity 46, member A
FHL2 four and a half LIM domains 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXF2 forkhead box F2
FRS2 fibroblast growth factor receptor substrate 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GATA6 GATA binding protein 6
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB10 growth factor receptor-bound protein 10
H3F3B H3 histone, family 3B (H3.3B)
HES1 hes family bHLH transcription factor 1
HIST1H2BG histone cluster 1, H2bg
HMGB2 high mobility group box 2
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IL6 interleukin 6
ING1 inhibitor of growth family, member 1
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
JARID2 jumonji, AT rich interactive domain 2
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
LBH limb bud and heart development
LEF1 lymphoid enhancer-binding factor 1
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MEG3 maternally expressed 3 (non-protein coding)
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1M metallothionein 1M
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMP22 peripheral myelin protein 22
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRAME preferentially expressed antigen in melanoma
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RAB20 RAB20, member RAS oncogene family
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RHOBTB3 Rho-related BTB domain containing 3
RND3 Rho family GTPase 3
RNMT RNA (guanine-7-) methyltransferase
RSRC2 arginine/serine-rich coiled-coil 2
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SEC24A SEC24 family member A
SFN stratifin
SIK1 salt-inducible kinase 1
SIRT1 sirtuin 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
STC2 stanniocalcin 2
TBX3 T-box 3
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM2 transmembrane protein 2
TRIB1 tribbles pseudokinase 1
TSC22D1 TSC22 domain family, member 1
TSPYL2 TSPY-like 2
TXNIP thioredoxin interacting protein
UBE2B ubiquitin-conjugating enzyme E2B
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALCAM activated leukocyte cell adhesion molecule
ANOS1 anosmin 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BHLHE41 basic helix-loop-helix family, member e41
C3 complement component 3
CA12 carbonic anhydrase XII
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD59 CD59 molecule, complement regulatory protein
CHRDL1 chordin-like 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLCA2 chloride channel accessory 2
CLU clusterin
CPE carboxypeptidase E
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DPYD dihydropyrimidine dehydrogenase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ERGIC2 ERGIC and golgi 2
FABP4 fatty acid binding protein 4, adipocyte
FASN fatty acid synthase
FGFR3 fibroblast growth factor receptor 3
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
ICMT isoprenylcysteine carboxyl methyltransferase
IFRD2 interferon-related developmental regulator 2
IGF1 insulin-like growth factor 1 (somatomedin C)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCTD12 potassium channel tetramerization domain containing 12
KIAA0930 KIAA0930
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT4 keratin 4, type II
KRT6A keratin 6A, type II
KYNU kynureninase
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
METTL7A methyltransferase like 7A
MME membrane metallo-endopeptidase
MREG melanoregulin
MRPS35 mitochondrial ribosomal protein S35
MSL1 male-specific lethal 1 homolog (Drosophila)
MSMO1 methylsterol monooxygenase 1
PDLIM5 PDZ and LIM domain 5
PDZK1IP1 PDZK1 interacting protein 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PIP prolactin-induced protein
POU2AF1 POU class 2 associating factor 1
PTGIS prostaglandin I2 (prostacyclin) synthase
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB2A2 secretoglobin, family 2A, member 2
SFRP4 secreted frizzled-related protein 4
SKAP2 src kinase associated phosphoprotein 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPRR1B small proline-rich protein 1B
SRPX sushi-repeat containing protein, X-linked
SRSF6 serine/arginine-rich splicing factor 6
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMBIM6 transmembrane BAX inhibitor motif containing 6
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TRIM14 tripartite motif containing 14
TRIM29 tripartite motif containing 29
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZMPSTE24 zinc metallopeptidase STE24