BRD-A24396574_celastrol_SKBR3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

312 genes differentially expressed following the BRD-A24396574_celastrol_SKBR3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABHD4 abhydrolase domain containing 4
ACOT13 acyl-CoA thioesterase 13
ADM adrenomedullin
AMDHD2 amidohydrolase domain containing 2
ANGPT1 angiopoietin 1
ATF3 activating transcription factor 3
ATF7IP activating transcription factor 7 interacting protein
AVPI1 arginine vasopressin-induced 1
BAG3 BCL2-associated athanogene 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CBS cystathionine-beta-synthase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHMP1B charged multivesicular body protein 1B
CLDN8 claudin 8
CST1 cystatin SN
CTH cystathionine gamma-lyase
CTSA cathepsin A
CTSL cathepsin L
CYB5R1 cytochrome b5 reductase 1
DDIT3 DNA-damage-inducible transcript 3
DENND1B DENN/MADD domain containing 1B
DLX2 distal-less homeobox 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DSP desmoplakin
DST dystonin
DUSP1 dual specificity phosphatase 1
EGF epidermal growth factor
ELL2 elongation factor, RNA polymerase II, 2
EMC3 ER membrane protein complex subunit 3
EMP3 epithelial membrane protein 3
FAM102A family with sequence similarity 102, member A
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
FTH1 ferritin, heavy polypeptide 1
FZD2 frizzled class receptor 2
GAB2 GRB2-associated binding protein 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GBAP1 glucosidase, beta, acid pseudogene 1
GCLC glutamate-cysteine ligase, catalytic subunit
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GPR137B G protein-coupled receptor 137B
GPRC5A G protein-coupled receptor, class C, group 5, member A
GREM1 gremlin 1, DAN family BMP antagonist
GTPBP2 GTP binding protein 2
HBP1 HMG-box transcription factor 1
HMOX1 heme oxygenase 1
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KEAP1 kelch-like ECH-associated protein 1
KLHL24 kelch-like family member 24
LCN2 lipocalin 2
LOR loricrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPK6 mitogen-activated protein kinase 6
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MDK midkine (neurite growth-promoting factor 2)
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYO10 myosin X
NCOA3 nuclear receptor coactivator 3
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NPC1 Niemann-Pick disease, type C1
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PHF1 PHD finger protein 1
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIR pirin (iron-binding nuclear protein)
PLIN2 perilipin 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRAME preferentially expressed antigen in melanoma
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PTPN12 protein tyrosine phosphatase, non-receptor type 12
QPCT glutaminyl-peptide cyclotransferase
QPRT quinolinate phosphoribosyltransferase
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RIOK3 RIO kinase 3
RNF13 ring finger protein 13
SAR1A secretion associated, Ras related GTPase 1A
SAT1 spermidine/spermine N1-acetyltransferase 1
SERINC5 serine incorporator 5
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC38A2 solute carrier family 38, member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SOWAHC sosondowah ankyrin repeat domain family member C
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SQSTM1 sequestosome 1
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TGIF1 TGFB-induced factor homeobox 1
TMEM2 transmembrane protein 2
TPP1 tripeptidyl peptidase I
TUFT1 tuftelin 1
UFD1L ubiquitin fusion degradation 1 like (yeast)
VEGFA vascular endothelial growth factor A
WNT5A wingless-type MMTV integration site family, member 5A
ZBTB43 zinc finger and BTB domain containing 43
ZCCHC6 zinc finger, CCHC domain containing 6
ZFAND5 zinc finger, AN1-type domain 5
ZMYM2 zinc finger, MYM-type 2
ZNF274 zinc finger protein 274
ZNF292 zinc finger protein 292
ZNF394 zinc finger protein 394
ZSCAN31 zinc finger and SCAN domain containing 31

decreased expression

Symbol Name
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ACSL3 acyl-CoA synthetase long-chain family member 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AHCY adenosylhomocysteinase
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANO1 anoctamin 1, calcium activated chloride channel
ANXA3 annexin A3
APOD apolipoprotein D
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPN asporin
BHLHE41 basic helix-loop-helix family, member e41
BST2 bone marrow stromal cell antigen 2
C1QBP complement component 1, q subcomponent binding protein
C3 complement component 3
C3ORF14 chromosome 3 open reading frame 14
C7 complement component 7
CA12 carbonic anhydrase XII
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND1 cyclin D1
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CFB complement factor B
CHRDL1 chordin-like 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLMN calmin (calponin-like, transmembrane)
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
COL3A1 collagen, type III, alpha 1
COL4A6 collagen, type IV, alpha 6
CPE carboxypeptidase E
CRIP1 cysteine-rich protein 1 (intestinal)
CRIP2 cysteine-rich protein 2
CXCL12 chemokine (C-X-C motif) ligand 12
CYB5A cytochrome b5 type A (microsomal)
DCK deoxycytidine kinase
DCN decorin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DHFR dihydrofolate reductase
DICER1 dicer 1, ribonuclease type III
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPT dermatopontin
DPYSL2 dihydropyrimidinase-like 2
DUT deoxyuridine triphosphatase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EHF ets homologous factor
EIF5A eukaryotic translation initiation factor 5A
FABP4 fatty acid binding protein 4, adipocyte
FAM120A family with sequence similarity 120A
FASN fatty acid synthase
FBL fibrillarin
FBLN1 fibulin 1
FHL1 four and a half LIM domains 1
FRZB frizzled-related protein
FSTL1 follistatin-like 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HADH hydroxyacyl-CoA dehydrogenase
ICMT isoprenylcysteine carboxyl methyltransferase
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
JCHAIN joining chain of multimeric IgA and IgM
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCTD12 potassium channel tetramerization domain containing 12
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KRT19 keratin 19, type I
KRT5 keratin 5, type II
KRT7 keratin 7, type II
LDHB lactate dehydrogenase B
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTF lactotransferrin
LUM lumican
LYPLA1 lysophospholipase I
LYZ lysozyme
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MBNL1 muscleblind-like splicing regulator 1
MCAM melanoma cell adhesion molecule
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
MYO5C myosin VC
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NBL1 neuroblastoma 1, DAN family BMP antagonist
NBN nibrin
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NEK2 NIMA-related kinase 2
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
OGN osteoglycin
PA2G4 proliferation-associated 2G4, 38kDa
PADI2 peptidyl arginine deiminase, type II
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PBX1 pre-B-cell leukemia homeobox 1
PFKM phosphofructokinase, muscle
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAC8 placenta-specific 8
PLN phospholamban
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRKCD protein kinase C, delta
PSIP1 PC4 and SFRS1 interacting protein 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PXDN peroxidasin
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS13 regulator of G-protein signaling 13
RPL22 ribosomal protein L22
RRM2 ribonucleotide reductase M2
S100A14 S100 calcium binding protein A14
S100A4 S100 calcium binding protein A4
SCG2 secretogranin II
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPDEF SAM pointed domain containing ETS transcription factor
SRM spermidine synthase
SRPX sushi-repeat containing protein, X-linked
SRSF1 serine/arginine-rich splicing factor 1
SRSF6 serine/arginine-rich splicing factor 6
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TFDP1 transcription factor Dp-1
TGFB3 transforming growth factor, beta 3
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMPO thymopoietin
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSPAN13 tetraspanin 13
TYMS thymidylate synthetase
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
VTCN1 V-set domain containing T cell activation inhibitor 1
WDR61 WD repeat domain 61
XBP1 X-box binding protein 1
ZDHHC6 zinc finger, DHHC-type containing 6
ZMIZ1 zinc finger, MIZ-type containing 1
ZWINT ZW10 interacting kinetochore protein