BRD-A24396574_celastrol_PC3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

117 genes differentially expressed following the BRD-A24396574_celastrol_PC3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRF5 adhesion G protein-coupled receptor F5
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AREG amphiregulin
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BLNK B-cell linker
BMP2 bone morphogenetic protein 2
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C3 complement component 3
CADM1 cell adhesion molecule 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CECR1 cat eye syndrome chromosome region, candidate 1
CHGB chromogranin B
CRP C-reactive protein, pentraxin-related
CTGF connective tissue growth factor
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DFNA5 deafness, autosomal dominant 5
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
FKBP11 FK506 binding protein 11, 19 kDa
GCG glucagon
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPX3 glutathione peroxidase 3
HLA-DMA major histocompatibility complex, class II, DM alpha
HSPA1A heat shock 70kDa protein 1A
IGFBP7 insulin-like growth factor binding protein 7
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
KCNK3 potassium channel, two pore domain subfamily K, member 3
KIF5C kinesin family member 5C
LAMP3 lysosomal-associated membrane protein 3
LAPTM4B lysosomal protein transmembrane 4 beta
MEF2C myocyte enhancer factor 2C
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PDGFRL platelet-derived growth factor receptor-like
PDZK1IP1 PDZK1 interacting protein 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PHACTR2 phosphatase and actin regulator 2
PLK2 polo-like kinase 2
POU2AF1 POU class 2 associating factor 1
PRKCQ protein kinase C, theta
RBP1 retinol binding protein 1, cellular
REG1B regenerating islet-derived 1 beta
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
RHOBTB3 Rho-related BTB domain containing 3
SCG2 secretogranin II
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIK1 salt-inducible kinase 1
SLAMF7 SLAM family member 7
SOD2 superoxide dismutase 2, mitochondrial
SPP1 secreted phosphoprotein 1
SST somatostatin
STC1 stanniocalcin 1
TBX2 T-box 2
TFPI2 tissue factor pathway inhibitor 2
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAV3 vav 3 guanine nucleotide exchange factor
VNN1 vanin 1
VWF von Willebrand factor
ZFPM2 zinc finger protein, FOG family member 2
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
AXIN1 axin 1
CDH3 cadherin 3, type 1, P-cadherin (placental)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COCH cochlin
DCK deoxycytidine kinase
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FLNA filamin A, alpha
FXYD3 FXYD domain containing ion transport regulator 3
GPI glucose-6-phosphate isomerase
HOXA10 homeobox A10
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
LAMA3 laminin, alpha 3
LBR lamin B receptor
LTF lactotransferrin
LYPLA1 lysophospholipase I
MYBPC1 myosin binding protein C, slow type
NET1 neuroepithelial cell transforming 1
NRIP1 nuclear receptor interacting protein 1
OAT ornithine aminotransferase
PDGFC platelet derived growth factor C
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRDX2 peroxiredoxin 2
PRKCA protein kinase C, alpha
RANBP2 RAN binding protein 2
RNASE4 ribonuclease, RNase A family, 4
SCP2 sterol carrier protein 2
SDC4 syndecan 4
SEC23A Sec23 homolog A (S. cerevisiae)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SPTAN1 spectrin, alpha, non-erythrocytic 1
TARP TCR gamma alternate reading frame protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TSPAN6 tetraspanin 6