BRD-A24396574_celastrol_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

121 genes differentially expressed following the BRD-A24396574_celastrol_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADGRG2 adhesion G protein-coupled receptor G2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CA2 carbonic anhydrase II
CARS cysteinyl-tRNA synthetase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLGN calmegin
CLU clusterin
CTH cystathionine gamma-lyase
CYBRD1 cytochrome b reductase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EGFR epidermal growth factor receptor
ELOVL5 ELOVL fatty acid elongase 5
ESRRG estrogen-related receptor gamma
FTL ferritin, light polypeptide
GABARAPL1 GABA(A) receptor-associated protein like 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GARS glycyl-tRNA synthetase
GATA3 GATA binding protein 3
GCLM glutamate-cysteine ligase, modifier subunit
GLUL glutamate-ammonia ligase
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
INSIG1 insulin induced gene 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JARID2 jumonji, AT rich interactive domain 2
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARCKS myristoylated alanine-rich protein kinase C substrate
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NEFM neurofilament, medium polypeptide
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PENK proenkephalin
PHGDH phosphoglycerate dehydrogenase
PROM1 prominin 1
PSAT1 phosphoserine aminotransferase 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RHOBTB3 Rho-related BTB domain containing 3
RPL37A ribosomal protein L37a
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQSTM1 sequestosome 1
STMN2 stathmin 2
SYBU syntabulin (syntaxin-interacting)
TAC1 tachykinin, precursor 1
TGFBI transforming growth factor, beta-induced, 68kDa
TRIB3 tribbles pseudokinase 3
TXN thioredoxin
VSNL1 visinin-like 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRL1 adhesion G protein-coupled receptor L1
ASPN asporin
ATM ATM serine/threonine kinase
CA12 carbonic anhydrase XII
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CTSK cathepsin K
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP6 dual specificity phosphatase 6
ERAP2 endoplasmic reticulum aminopeptidase 2
ESR1 estrogen receptor 1
ETV1 ets variant 1
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FBP1 fructose-1,6-bisphosphatase 1
FHL1 four and a half LIM domains 1
GPER1 G protein-coupled estrogen receptor 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2AFV H2A histone family, member V
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IGFBP3 insulin-like growth factor binding protein 3
KIAA0101 KIAA0101
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LYZ lysozyme
MREG melanoregulin
MYH11 myosin, heavy chain 11, smooth muscle
NOX4 NADPH oxidase 4
PALLD palladin, cytoskeletal associated protein
PDLIM3 PDZ and LIM domain 3
PLN phospholamban
RGS2 regulator of G-protein signaling 2
RNF144A ring finger protein 144A
RRM2 ribonucleotide reductase M2
SFRP1 secreted frizzled-related protein 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
ST14 suppression of tumorigenicity 14 (colon carcinoma)
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2C ubiquitin-conjugating enzyme E2C
ZWINT ZW10 interacting kinetochore protein