BRD-A24396574_celastrol_MDAMB231_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

62 genes differentially expressed following the BRD-A24396574_celastrol_MDAMB231_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
CCR7 chemokine (C-C motif) receptor 7
CKS2 CDC28 protein kinase regulatory subunit 2
CREM cAMP responsive element modulator
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EGR3 early growth response 3
EMX2 empty spiracles homeobox 2
FAS Fas cell surface death receptor
FGFR2 fibroblast growth factor receptor 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
HAL histidine ammonia-lyase
HEPH hephaestin
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
HOXA10 homeobox A10
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IER5 immediate early response 5
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
KIF5C kinesin family member 5C
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
LBH limb bud and heart development
MAOB monoamine oxidase B
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYLK myosin light chain kinase
NOTCH3 notch 3
NR4A3 nuclear receptor subfamily 4, group A, member 3
PRR15L proline rich 15-like
RGS2 regulator of G-protein signaling 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TBX3 T-box 3
TGFBI transforming growth factor, beta-induced, 68kDa
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
CD9 CD9 molecule
CPE carboxypeptidase E
CREB1 cAMP responsive element binding protein 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
FABP4 fatty acid binding protein 4, adipocyte
FHL1 four and a half LIM domains 1
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
MAGEA3 melanoma antigen family A3
MMP12 matrix metallopeptidase 12
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
SPP1 secreted phosphoprotein 1
THAP11 THAP domain containing 11