BRD-A24396574_celastrol_MDAMB231_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-A24396574_celastrol_MDAMB231_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ATF3 activating transcription factor 3
C1ORF116 chromosome 1 open reading frame 116
CLDN10 claudin 10
CLU clusterin
COL13A1 collagen, type XIII, alpha 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
EIF4A1 eukaryotic translation initiation factor 4A1
EPN2 epsin 2
FAM13A family with sequence similarity 13, member A
GBP2 guanylate binding protein 2, interferon-inducible
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
JAM3 junctional adhesion molecule 3
JUN jun proto-oncogene
KYNU kynureninase
L1CAM L1 cell adhesion molecule
LEF1 lymphoid enhancer-binding factor 1
MAL mal, T-cell differentiation protein
MAN1C1 mannosidase, alpha, class 1C, member 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NRCAM neuronal cell adhesion molecule
PBX1 pre-B-cell leukemia homeobox 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLAGL1 pleiomorphic adenoma gene-like 1
RHOBTB3 Rho-related BTB domain containing 3
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
TARP TCR gamma alternate reading frame protein
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIM16 tripartite motif containing 16
ZIC1 Zic family member 1
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
AVL9 AVL9 homolog (S. cerevisiase)
CBX3 chromobox homolog 3
CCL19 chemokine (C-C motif) ligand 19
CCND2 cyclin D2
CD24 CD24 molecule
CSTA cystatin A (stefin A)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
DEFB1 defensin, beta 1
DST dystonin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPCAM epithelial cell adhesion molecule
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FAS Fas cell surface death receptor
FKBP9 FK506 binding protein 9, 63 kDa
G0S2 G0/G1 switch 2
GARS glycyl-tRNA synthetase
GGCT gamma-glutamylcyclotransferase
GSTP1 glutathione S-transferase pi 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KLF5 Kruppel-like factor 5 (intestinal)
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LCN2 lipocalin 2
LDHB lactate dehydrogenase B
LGALS1 lectin, galactoside-binding, soluble, 1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAOA monoamine oxidase A
MFAP5 microfibrillar associated protein 5
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MSX1 msh homeobox 1
NUSAP1 nucleolar and spindle associated protein 1
OLFM4 olfactomedin 4
PLA2G16 phospholipase A2, group XVI
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PRSS8 protease, serine, 8
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPL36 ribosomal protein L36
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SIRT3 sirtuin 3
SNRPE small nuclear ribonucleoprotein polypeptide E
SPP1 secreted phosphoprotein 1
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
TWF1 twinfilin actin binding protein 1
VTCN1 V-set domain containing T cell activation inhibitor 1