BRD-A24396574_celastrol_MCF7_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

66 genes differentially expressed following the BRD-A24396574_celastrol_MCF7_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
C7 complement component 7
CCND2 cyclin D2
CD200 CD200 molecule
CLEC11A C-type lectin domain family 11, member A
CPE carboxypeptidase E
CST7 cystatin F (leukocystatin)
CTSC cathepsin C
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
FOS FBJ murine osteosarcoma viral oncogene homolog
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GOLGA8B golgin A8 family, member B
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IGFBP7 insulin-like growth factor binding protein 7
JMJD6 jumonji domain containing 6
JUNB jun B proto-oncogene
MPO myeloperoxidase
MYLIP myosin regulatory light chain interacting protein
NR2F2 nuclear receptor subfamily 2, group F, member 2
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PEG3 paternally expressed 3
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
RSRP1 arginine/serine-rich protein 1
SCGB1D2 secretoglobin, family 1D, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP4 secreted frizzled-related protein 4
SOX9 SRY (sex determining region Y)-box 9
STK10 serine/threonine kinase 10
TIMP1 TIMP metallopeptidase inhibitor 1
TLR4 toll-like receptor 4
TRAC T cell receptor alpha constant

decreased expression

Symbol Name
ANGPT1 angiopoietin 1
CLCA4 chloride channel accessory 4
CST1 cystatin SN
DCK deoxycytidine kinase
EMP2 epithelial membrane protein 2
FAM134B family with sequence similarity 134, member B
FAM60A family with sequence similarity 60, member A
FHL1 four and a half LIM domains 1
FMO5 flavin containing monooxygenase 5
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GDF15 growth differentiation factor 15
GREM1 gremlin 1, DAN family BMP antagonist
HOXA10 homeobox A10
LOX lysyl oxidase
MDK midkine (neurite growth-promoting factor 2)
MME membrane metallo-endopeptidase
PCP4 Purkinje cell protein 4
PRKD3 protein kinase D3
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
SDC1 syndecan 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPP1 secreted phosphoprotein 1
STOM stomatin
THBS1 thrombospondin 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TXNIP thioredoxin interacting protein