BRD-A24396574_celastrol_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

293 genes differentially expressed following the BRD-A24396574_celastrol_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANKRD11 ankyrin repeat domain 11
ANKRD12 ankyrin repeat domain 12
AQP3 aquaporin 3 (Gill blood group)
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ARMCX3 armadillo repeat containing, X-linked 3
ASPH aspartate beta-hydroxylase
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BMP2 bone morphogenetic protein 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BRD4 bromodomain containing 4
BTG3 BTG family, member 3
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
CSRP2 cysteine and glycine-rich protein 2
CYLD cylindromatosis (turban tumor syndrome)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EGF epidermal growth factor
EGR1 early growth response 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EMP3 epithelial membrane protein 3
ETV5 ets variant 5
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXD1 forkhead box D1
FSCN1 fascin actin-bundling protein 1
FXR1 fragile X mental retardation, autosomal homolog 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GRB10 growth factor receptor-bound protein 10
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL1R2 interleukin 1 receptor, type II
IL6R interleukin 6 receptor
ISG20 interferon stimulated exonuclease gene 20kDa
ITCH itchy E3 ubiquitin protein ligase
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF10 Kruppel-like factor 10
KLF5 Kruppel-like factor 5 (intestinal)
KLHL24 kelch-like family member 24
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMB3 laminin, beta 3
LIF leukemia inhibitory factor
LOX lysyl oxidase
LRIF1 ligand dependent nuclear receptor interacting factor 1
LYPD1 LY6/PLAUR domain containing 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYO10 myosin X
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NPTX2 neuronal pentraxin II
NRN1 neuritin 1
OSER1 oxidative stress responsive serine-rich 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PHGDH phosphoglycerate dehydrogenase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRNP prion protein
RAD9A RAD9 homolog A (S. pombe)
RANBP2 RAN binding protein 2
RGS2 regulator of G-protein signaling 2
RHOF ras homolog family member F (in filopodia)
RIT1 Ras-like without CAAX 1
RRAGD Ras-related GTP binding D
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEC24A SEC24 family member A
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFN stratifin
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SMOX spermine oxidase
SPAG9 sperm associated antigen 9
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SQSTM1 sequestosome 1
SRGN serglycin
STXBP1 syntaxin binding protein 1
TBL2 transducin (beta)-like 2
TDO2 tryptophan 2,3-dioxygenase
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM45A transmembrane protein 45A
TUBA4A tubulin, alpha 4a
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
ZBTB43 zinc finger and BTB domain containing 43

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
AIM1 absent in melanoma 1
ANXA3 annexin A3
AOX1 aldehyde oxidase 1
AREG amphiregulin
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARMT1 acidic residue methyltransferase 1
B3GNT1
BCL2 B-cell CLL/lymphoma 2
BLVRA biliverdin reductase A
C14ORF132 chromosome 14 open reading frame 132
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCDC109B coiled-coil domain containing 109B
CCNA2 cyclin A2
CCND1 cyclin D1
CD200 CD200 molecule
CDK1 cyclin-dependent kinase 1
CFB complement factor B
CHRDL1 chordin-like 1
CLIC3 chloride intracellular channel 3
CXCL10 chemokine (C-X-C motif) ligand 10
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCXR dicarbonyl/L-xylulose reductase
DEPTOR DEP domain containing MTOR-interacting protein
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYD dihydropyrimidine dehydrogenase
DUT deoxyuridine triphosphatase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
FBP1 fructose-1,6-bisphosphatase 1
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATA3 GATA binding protein 3
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GREB1 growth regulation by estrogen in breast cancer 1
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HELLS helicase, lymphoid-specific
HIST1H4C histone cluster 1, H4c
HMGB3 high mobility group box 3
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
ICMT isoprenylcysteine carboxyl methyltransferase
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGF1R insulin-like growth factor 1 receptor
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
ISOC1 isochorismatase domain containing 1
JCHAIN joining chain of multimeric IgA and IgM
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KRT19 keratin 19, type I
LEPR leptin receptor
LMNB1 lamin B1
LOXL1 lysyl oxidase-like 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCKSL1 MARCKS-like 1
MCM2 minichromosome maintenance complex component 2
MCM6 minichromosome maintenance complex component 6
MEIS2 Meis homeobox 2
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MLPH melanophilin
MREG melanoregulin
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MXRA5 matrix-remodelling associated 5
MYB v-myb avian myeloblastosis viral oncogene homolog
MYCBP MYC binding protein
MYOF myoferlin
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAV2 neuron navigator 2
NBL1 neuroblastoma 1, DAN family BMP antagonist
NHP2 NHP2 ribonucleoprotein
NME1 NME/NM23 nucleoside diphosphate kinase 1
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAWR PRKC, apoptosis, WT1, regulator
PBX1 pre-B-cell leukemia homeobox 1
PCCB propionyl CoA carboxylase, beta polypeptide
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFD platelet derived growth factor D
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLK1 polo-like kinase 1
PLS1 plastin 1
PODXL podocalyxin-like
PPT1 palmitoyl-protein thioesterase 1
PRSS23 protease, serine, 23
RBBP7 retinoblastoma binding protein 7
RBPMS RNA binding protein with multiple splicing
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPIA ribose 5-phosphate isomerase A
RPL22 ribosomal protein L22
RRM2 ribonucleotide reductase M2
RUVBL1 RuvB-like AAA ATPase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
SRI sorcin
SRSF1 serine/arginine-rich splicing factor 1
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCF3 transcription factor 3
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TMEM106C transmembrane protein 106C
TMEM109 transmembrane protein 109
TMEM14A transmembrane protein 14A
TMPO thymopoietin
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TRPS1 trichorhinophalangeal syndrome I
TSPAN13 tetraspanin 13
TUBA1A tubulin, alpha 1a
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UGDH UDP-glucose 6-dehydrogenase
VAMP8 vesicle-associated membrane protein 8
VTCN1 V-set domain containing T cell activation inhibitor 1