BRD-A24396574_celastrol_MCF7_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

68 genes differentially expressed following the BRD-A24396574_celastrol_MCF7_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
AKAP12 A kinase (PRKA) anchor protein 12
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CCND2 cyclin D2
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDK12 cyclin-dependent kinase 12
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CX3CR1 chemokine (C-X3-C motif) receptor 1
DCN decorin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGBP Fc fragment of IgG binding protein
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
HIST1H2AE histone cluster 1, H2ae
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER2 immediate early response 2
IER5 immediate early response 5
IGFBP7 insulin-like growth factor binding protein 7
ITGA7 integrin, alpha 7
JUNB jun B proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KRT17 keratin 17, type I
KRT20 keratin 20, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KYNU kynureninase
MAST2 microtubule associated serine/threonine kinase 2
MX1 MX dynamin-like GTPase 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
PCGF2 polycomb group ring finger 2
PILRB paired immunoglobin-like type 2 receptor beta
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
RNASET2 ribonuclease T2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SFN stratifin
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TMEM45A transmembrane protein 45A
TSPAN7 tetraspanin 7
TYROBP TYRO protein tyrosine kinase binding protein
VNN1 vanin 1

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
CD24 CD24 molecule
CLU clusterin
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
ENO1 enolase 1, (alpha)
FABP7 fatty acid binding protein 7, brain
FAS Fas cell surface death receptor
KIAA0125 KIAA0125
KLHL21 kelch-like family member 21
MAGED1 melanoma antigen family D1
MOSPD1 motile sperm domain containing 1
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
SRSF7 serine/arginine-rich splicing factor 7