BRD-A24396574_celastrol_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-A24396574_celastrol_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADGRG2 adhesion G protein-coupled receptor G2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BEX1 brain expressed, X-linked 1
C1S complement component 1, s subcomponent
C3ORF14 chromosome 3 open reading frame 14
CD52 CD52 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLGN calmegin
COL6A2 collagen, type VI, alpha 2
CSRP2 cysteine and glycine-rich protein 2
CTSE cathepsin E
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
FGG fibrinogen gamma chain
GATA3 GATA binding protein 3
GCLM glutamate-cysteine ligase, modifier subunit
GJA1 gap junction protein, alpha 1, 43kDa
GPX2 glutathione peroxidase 2
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
ITM2A integral membrane protein 2A
JMJD6 jumonji domain containing 6
KIF14 kinesin family member 14
KRT19 keratin 19, type I
LBH limb bud and heart development
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP1B microtubule-associated protein 1B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NQO1 NAD(P)H dehydrogenase, quinone 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PIR pirin (iron-binding nuclear protein)
PLIN2 perilipin 2
PLS3 plastin 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRKCB protein kinase C, beta
RND3 Rho family GTPase 3
S100A7 S100 calcium binding protein A7
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFRP1 secreted frizzled-related protein 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNAP25 synaptosomal-associated protein, 25kDa
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
STMN2 stathmin 2
TAGLN transgelin
TBX3 T-box 3
TFPI2 tissue factor pathway inhibitor 2
TMEM47 transmembrane protein 47
TMEM97 transmembrane protein 97
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WBP5 WW domain binding protein 5
ZC3HAV1 zinc finger CCCH-type, antiviral 1

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
BLNK B-cell linker
CARD10 caspase recruitment domain family, member 10
COG7 component of oligomeric golgi complex 7
CST3 cystatin C
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EMP3 epithelial membrane protein 3
EREG epiregulin
FLT3 fms-related tyrosine kinase 3
GOLM1 golgi membrane protein 1
HES1 hes family bHLH transcription factor 1
IER3 immediate early response 3
IL13RA2 interleukin 13 receptor, alpha 2
IL1B interleukin 1, beta
KLF6 Kruppel-like factor 6
LIPG lipase, endothelial
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MGLL monoglyceride lipase
MT2A metallothionein 2A
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOS3 nitric oxide synthase 3 (endothelial cell)
NPIPB3 nuclear pore complex interacting protein family, member B3
NT5E 5'-nucleotidase, ecto (CD73)
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFA platelet-derived growth factor alpha polypeptide
PDGFC platelet derived growth factor C
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB31 RAB31, member RAS oncogene family
RNF130 ring finger protein 130
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPAG4 sperm associated antigen 4
THBS1 thrombospondin 1
TXNIP thioredoxin interacting protein
ZBED2 zinc finger, BED-type containing 2
ZNF185 zinc finger protein 185 (LIM domain)