BRD-A24396574_celastrol_LNCAP_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-A24396574_celastrol_LNCAP_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BCL10 B-cell CLL/lymphoma 10
BRD4 bromodomain containing 4
C10ORF10 chromosome 10 open reading frame 10
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFNB2 ephrin-B2
EGR1 early growth response 1
EGR3 early growth response 3
FMO1 flavin containing monooxygenase 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GEM GTP binding protein overexpressed in skeletal muscle
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBD hemoglobin, delta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IL1R2 interleukin 1 receptor, type II
JMJD6 jumonji domain containing 6
JUNB jun B proto-oncogene
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT13 keratin 13, type I
KRT19 keratin 19, type I
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MCL1 myeloid cell leukemia 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OSER1 oxidative stress responsive serine-rich 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RGS1 regulator of G-protein signaling 1
RHOB ras homolog family member B
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A2 solute carrier family 38, member 2
SPP1 secreted phosphoprotein 1
SPRR3 small proline-rich protein 3
SPRY4 sprouty homolog 4 (Drosophila)
SRGN serglycin
TGIF1 TGFB-induced factor homeobox 1
VCAM1 vascular cell adhesion molecule 1
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
APOD apolipoprotein D
ARHGAP29 Rho GTPase activating protein 29
ASCL1 achaete-scute family bHLH transcription factor 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD47 CD47 molecule
CD9 CD9 molecule
CFB complement factor B
CIRBP cold inducible RNA binding protein
CPE carboxypeptidase E
CTSH cathepsin H
CXCL14 chemokine (C-X-C motif) ligand 14
DDHD2 DDHD domain containing 2
EXT1 exostosin glycosyltransferase 1
GPER1 G protein-coupled estrogen receptor 1
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSTA4 glutathione S-transferase alpha 4
LAPTM4B lysosomal protein transmembrane 4 beta
LIMCH1 LIM and calponin homology domains 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYPLA1 lysophospholipase I
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MT1E metallothionein 1E
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa
NMU neuromedin U
NRN1 neuritin 1
OLFM4 olfactomedin 4
PARP1 poly (ADP-ribose) polymerase 1
PCP4 Purkinje cell protein 4
PEG10 paternally expressed 10
SCARB2 scavenger receptor class B, member 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TPD52 tumor protein D52
TXNIP thioredoxin interacting protein