BRD-A24396574_celastrol_LNCAP_3_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-A24396574_celastrol_LNCAP_3_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADO 2-aminoethanethiol (cysteamine) dioxygenase
CCND2 cyclin D2
COL9A2 collagen, type IX, alpha 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
DICER1 dicer 1, ribonuclease type III
FRZB frizzled-related protein
GSTT1 glutathione S-transferase theta 1
HBD hemoglobin, delta
HHEX hematopoietically expressed homeobox
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
IGHD immunoglobulin heavy constant delta
KRT23 keratin 23, type I
LGALS3 lectin, galactoside-binding, soluble, 3
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MDK midkine (neurite growth-promoting factor 2)
METTL7A methyltransferase like 7A
MMP7 matrix metallopeptidase 7
MTSS1 metastasis suppressor 1
MXRA7 matrix-remodelling associated 7
NBL1 neuroblastoma 1, DAN family BMP antagonist
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
PLBD1 phospholipase B domain containing 1
PTN pleiotrophin
RBP1 retinol binding protein 1, cellular
RGS1 regulator of G-protein signaling 1
RGS5 regulator of G-protein signaling 5
RNASE6 ribonuclease, RNase A family, k6
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SCG5 secretogranin V
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SOX9 SRY (sex determining region Y)-box 9
TGFA transforming growth factor, alpha
TIMP1 TIMP metallopeptidase inhibitor 1

decreased expression

Symbol Name
B3GNT1
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
C6ORF62 chromosome 6 open reading frame 62
CALR calreticulin
CDC25B cell division cycle 25B
CLIC4 chloride intracellular channel 4
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL1A1 collagen, type I, alpha 1
CUL4B cullin 4B
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EIF5 eukaryotic translation initiation factor 5
ELAVL1 ELAV like RNA binding protein 1
ERAP2 endoplasmic reticulum aminopeptidase 2
ETV1 ets variant 1
GLUL glutamate-ammonia ligase
HOXC6 homeobox C6
JADE2 jade family PHD finger 2
LOX lysyl oxidase
LRRC16A leucine rich repeat containing 16A
MAT2A methionine adenosyltransferase II, alpha
MBD2 methyl-CpG binding domain protein 2
NONO non-POU domain containing, octamer-binding
OLFM1 olfactomedin 1
PDLIM5 PDZ and LIM domain 5
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCD protein kinase C, delta
REEP5 receptor accessory protein 5
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SEPT2 septin 2
SET SET nuclear proto-oncogene
SRSF1 serine/arginine-rich splicing factor 1
SS18 synovial sarcoma translocation, chromosome 18
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TPM4 tropomyosin 4
TRAM1 translocation associated membrane protein 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta