BRD-A24396574_celastrol_LNCAP_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

310 genes differentially expressed following the BRD-A24396574_celastrol_LNCAP_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACOT13 acyl-CoA thioesterase 13
ADGRG2 adhesion G protein-coupled receptor G2
ADM adrenomedullin
AIF1 allograft inflammatory factor 1
AKAP17A A kinase (PRKA) anchor protein 17A
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AMDHD2 amidohydrolase domain containing 2
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASF1A anti-silencing function 1A histone chaperone
ATF3 activating transcription factor 3
ATF6 activating transcription factor 6
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BHLHE41 basic helix-loop-helix family, member e41
BLVRB biliverdin reductase B
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBR3 carbonyl reductase 3
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEMIP cell migration inducing protein, hyaluronan binding
CLEC2B C-type lectin domain family 2, member B
CLIC2 chloride intracellular channel 2
CLU clusterin
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL1A1 collagen, type I, alpha 1
COL5A2 collagen, type V, alpha 2
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
CTSA cathepsin A
CTSD cathepsin D
CXCR4 chemokine (C-X-C motif) receptor 4
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT3 DNA-damage-inducible transcript 3
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DEFB1 defensin, beta 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
EGF epidermal growth factor
EGR1 early growth response 1
ELL2 elongation factor, RNA polymerase II, 2
EMX2 empty spiracles homeobox 2
F13A1 coagulation factor XIII, A1 polypeptide
FAM46A family with sequence similarity 46, member A
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FNDC3B fibronectin type III domain containing 3B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FTH1 ferritin, heavy polypeptide 1
FTL ferritin, light polypeptide
GAB2 GRB2-associated binding protein 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GCLM glutamate-cysteine ligase, modifier subunit
GLRX glutaredoxin (thioltransferase)
GNPDA1 glucosamine-6-phosphate deaminase 1
GPR137B G protein-coupled receptor 137B
GPX3 glutathione peroxidase 3
GRN granulin
H1F0 H1 histone family, member 0
HBD hemoglobin, delta
HECA headcase homolog (Drosophila)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2BC histone cluster 1, H2bc
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IL6 interleukin 6
IRF7 interferon regulatory factor 7
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KDM3A lysine (K)-specific demethylase 3A
KDM5A lysine (K)-specific demethylase 5A
KIAA0907 KIAA0907
KIAA1551 KIAA1551
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
KRT18 keratin 18, type I
LAMP2 lysosomal-associated membrane protein 2
LGALS8 lectin, galactoside-binding, soluble, 8
LIF leukemia inhibitory factor
LRIF1 ligand dependent nuclear receptor interacting factor 1
LYN LYN proto-oncogene, Src family tyrosine kinase
LYPD1 LY6/PLAUR domain containing 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAGEB2 melanoma antigen family B2
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MCOLN1 mucolipin 1
MCUR1 mitochondrial calcium uniporter regulator 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP5 microfibrillar associated protein 5
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOSPD1 motile sperm domain containing 1
MSRB1 methionine sulfoxide reductase B1
MYO10 myosin X
NAMPT nicotinamide phosphoribosyltransferase
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NOS3 nitric oxide synthase 3 (endothelial cell)
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRCAM neuronal cell adhesion molecule
OSBPL3 oxysterol binding protein-like 3
OSER1 oxidative stress responsive serine-rich 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCSK5 proprotein convertase subtilisin/kexin type 5
PELI1 pellino E3 ubiquitin protein ligase 1
PERP PERP, TP53 apoptosis effector
PLIN2 perilipin 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RAB29 RAB29, member RAS oncogene family
RAB9A RAB9A, member RAS oncogene family
RAE1 ribonucleic acid export 1
RANBP9 RAN binding protein 9
RBM6 RNA binding motif protein 6
RIN3 Ras and Rab interactor 3
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND1 Rho family GTPase 1
RND3 Rho family GTPase 3
RNF114 ring finger protein 114
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RRAGC Ras-related GTP binding C
RRAGD Ras-related GTP binding D
RUNX3 runt-related transcription factor 3
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SEC24A SEC24 family member A
SEPP1 selenoprotein P, plasma, 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SOX9 SRY (sex determining region Y)-box 9
SPARCL1 SPARC-like 1 (hevin)
SQSTM1 sequestosome 1
STAB1 stabilin 1
STK17A serine/threonine kinase 17a
STX3 syntaxin 3
TBPL1 TBP-like 1
TES testin LIM domain protein
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM2 transmembrane protein 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPM4 tropomyosin 4
TPP1 tripeptidyl peptidase I
TSPAN8 tetraspanin 8
TUBB2B tubulin, beta 2B class IIb
TXN thioredoxin
TYMP thymidine phosphorylase
TYROBP TYRO protein tyrosine kinase binding protein
UBE2B ubiquitin-conjugating enzyme E2B
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WBP5 WW domain binding protein 5
WSB1 WD repeat and SOCS box containing 1
WT1 Wilms tumor 1
YAP1 Yes-associated protein 1
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZNF165 zinc finger protein 165
ZNF292 zinc finger protein 292
ZNF394 zinc finger protein 394

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACKR3 atypical chemokine receptor 3
ACLY ATP citrate lyase
ADCY9 adenylate cyclase 9
ADD3 adducin 3 (gamma)
ADGRG6 adhesion G protein-coupled receptor G6
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGTR1 angiotensin II receptor, type 1
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALCAM activated leukocyte cell adhesion molecule
AMD1 adenosylmethionine decarboxylase 1
B3GNT1
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
BTBD1 BTB (POZ) domain containing 1
C3 complement component 3
CA12 carbonic anhydrase XII
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CPNE3 copine III
DCK deoxycytidine kinase
DCN decorin
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYD dihydropyrimidine dehydrogenase
DUT deoxyuridine triphosphatase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELOVL5 ELOVL fatty acid elongase 5
FHL1 four and a half LIM domains 1
GBAS glioblastoma amplified sequence
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H4C histone cluster 1, H4c
HLTF helicase-like transcription factor
HMGN3 high mobility group nucleosomal binding domain 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
LDHB lactate dehydrogenase B
LEPR leptin receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIPA lipase A, lysosomal acid, cholesterol esterase
LMNB1 lamin B1
LUM lumican
LYPLA1 lysophospholipase I
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MBOAT2 membrane bound O-acyltransferase domain containing 2
MME membrane metallo-endopeptidase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCBP MYC binding protein
MYH10 myosin, heavy chain 10, non-muscle
NEK2 NIMA-related kinase 2
NFIB nuclear factor I/B
NREP neuronal regeneration related protein
NT5E 5'-nucleotidase, ecto (CD73)
NTS neurotensin
NUSAP1 nucleolar and spindle associated protein 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCCB propionyl CoA carboxylase, beta polypeptide
PDE9A phosphodiesterase 9A
PDHB pyruvate dehydrogenase (lipoamide) beta
PGRMC2 progesterone receptor membrane component 2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLCB4 phospholipase C, beta 4
PLK1 polo-like kinase 1
PSD3 pleckstrin and Sec7 domain containing 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTTG1 pituitary tumor-transforming 1
RAB4A RAB4A, member RAS oncogene family
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
REEP5 receptor accessory protein 5
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPL22 ribosomal protein L22
RPL39L ribosomal protein L39-like
RRM2 ribonucleotide reductase M2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SNAP25 synaptosomal-associated protein, 25kDa
SPDEF SAM pointed domain containing ETS transcription factor
SULF1 sulfatase 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCF3 transcription factor 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TMEM14A transmembrane protein 14A
TMEM165 transmembrane protein 165
TMPO thymopoietin
TOB1 transducer of ERBB2, 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIP13 thyroid hormone receptor interactor 13
TSPYL5 TSPY-like 5
TUSC3 tumor suppressor candidate 3
UBE2C ubiquitin-conjugating enzyme E2C
UQCRC2 ubiquinol-cytochrome c reductase core protein II