BRD-A24396574_celastrol_HS578T_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-A24396574_celastrol_HS578T_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARG1 arginase 1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BPI bactericidal/permeability-increasing protein
C5AR1 complement component 5a receptor 1
CACYBP calcyclin binding protein
CD300A CD300a molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CECR1 cat eye syndrome chromosome region, candidate 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COBL cordon-bleu WH2 repeat protein
CTH cystathionine gamma-lyase
DAPK1 death-associated protein kinase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNTT DNA nucleotidylexotransferase
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GDF15 growth differentiation factor 15
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
HOMER1 homer scaffolding protein 1
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLV2-23 immunoglobulin lambda variable 2-23
IL6 interleukin 6
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
JMJD6 jumonji domain containing 6
JUNB jun B proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
KDM6B lysine (K)-specific demethylase 6B
KLF4 Kruppel-like factor 4 (gut)
KRT81 keratin 81, type II
LYPD1 LY6/PLAUR domain containing 1
MMP7 matrix metallopeptidase 7
MPO myeloperoxidase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAC8 placenta-specific 8
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGS2 regulator of G-protein signaling 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN8 tetraspanin 8
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
APOD apolipoprotein D
AREG amphiregulin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASPH aspartate beta-hydroxylase
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CCL19 chemokine (C-C motif) ligand 19
CCNE2 cyclin E2
CD59 CD59 molecule, complement regulatory protein
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CPE carboxypeptidase E
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
DEPTOR DEP domain containing MTOR-interacting protein
DPT dermatopontin
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPNMB glycoprotein (transmembrane) nmb
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ITGAV integrin, alpha V
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LAMA3 laminin, alpha 3
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAP7 microtubule-associated protein 7
MEIS1 Meis homeobox 1
MMP9 matrix metallopeptidase 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PRPF4 pre-mRNA processing factor 4
SEPP1 selenoprotein P, plasma, 1
TARDBP TAR DNA binding protein
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TNC tenascin C
WT1 Wilms tumor 1