BRD-A24396574_celastrol_HS578T_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

308 genes differentially expressed following the BRD-A24396574_celastrol_HS578T_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ANKRD10 ankyrin repeat domain 10
AQP1 aquaporin 1 (Colton blood group)
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCL6 B-cell CLL/lymphoma 6
BID BH3 interacting domain death agonist
C21ORF91 chromosome 21 open reading frame 91
C5AR1 complement component 5a receptor 1
CACYBP calcyclin binding protein
CADM1 cell adhesion molecule 1
CCDC59 coiled-coil domain containing 59
CD163 CD163 molecule
CD200 CD200 molecule
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC25A cell division cycle 25A
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHIC2 cysteine-rich hydrophobic domain 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CRABP1 cellular retinoic acid binding protein 1
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTGF connective tissue growth factor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
DACH1 dachshund family transcription factor 1
DDIT3 DNA-damage-inducible transcript 3
DENND1B DENN/MADD domain containing 1B
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP6 dual specificity phosphatase 6
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGR1 early growth response 1
EGR3 early growth response 3
EMX2 empty spiracles homeobox 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHB2 EPH receptor B2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
EZR ezrin
F13A1 coagulation factor XIII, A1 polypeptide
FABP1 fatty acid binding protein 1, liver
FABP4 fatty acid binding protein 4, adipocyte
FBXO11 F-box protein 11
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FGL2 fibrinogen-like 2
FILIP1L filamin A interacting protein 1-like
FMOD fibromodulin
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAS GNAS complex locus
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H2AE histone cluster 1, H2ae
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HMOX1 heme oxygenase 1
HRG histidine-rich glycoprotein
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA4 heat shock 70kDa protein 4
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IL10RA interleukin 10 receptor, alpha
IL18 interleukin 18
IL1R2 interleukin 1 receptor, type II
IL6 interleukin 6
ITM2A integral membrane protein 2A
JMJD6 jumonji domain containing 6
JUNB jun B proto-oncogene
KDM5B lysine (K)-specific demethylase 5B
KDM7A lysine (K)-specific demethylase 7A
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
KRT13 keratin 13, type I
KRT18 keratin 18, type I
LCN2 lipocalin 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MGAM maltase-glucoamylase
MICB MHC class I polypeptide-related sequence B
MIR22HG MIR22 host gene
MNDA myeloid cell nuclear differentiation antigen
MTSS1 metastasis suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
NCF2 neutrophil cytosolic factor 2
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEU1 sialidase 1 (lysosomal sialidase)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
ODC1 ornithine decarboxylase 1
OSER1 oxidative stress responsive serine-rich 1
PELI1 pellino E3 ubiquitin protein ligase 1
PI3 peptidase inhibitor 3, skin-derived
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLBD1 phospholipase B domain containing 1
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R10 protein phosphatase 1, regulatory subunit 10
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
QPRT quinolinate phosphoribosyltransferase
RAB29 RAB29, member RAS oncogene family
RAE1 ribonucleic acid export 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RNF114 ring finger protein 114
RNMT RNA (guanine-7-) methyltransferase
RPL37A ribosomal protein L37a
RRAD Ras-related associated with diabetes
RRAGD Ras-related GTP binding D
RYBP RING1 and YY1 binding protein
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SERINC5 serine incorporator 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SIK3 SIK family kinase 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRR3 small proline-rich protein 3
ST7 suppression of tumorigenicity 7
STX3 syntaxin 3
SUCO SUN domain containing ossification factor
TDO2 tryptophan 2,3-dioxygenase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM100 transmembrane protein 100
TOB1 transducer of ERBB2, 1
TRIB1 tribbles pseudokinase 1
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TUFT1 tuftelin 1
UBXN7 UBX domain protein 7
UFD1L ubiquitin fusion degradation 1 like (yeast)
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4
WASF3 WAS protein family, member 3
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZNF274 zinc finger protein 274
ZNF331 zinc finger protein 331
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADAM9 ADAM metallopeptidase domain 9
ADD3 adducin 3 (gamma)
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALCAM activated leukocyte cell adhesion molecule
ANPEP alanyl (membrane) aminopeptidase
ANXA7 annexin A7
ARHGAP29 Rho GTPase activating protein 29
ARMCX2 armadillo repeat containing, X-linked 2
ASPH aspartate beta-hydroxylase
CAV1 caveolin 1, caveolae protein, 22kDa
CD151 CD151 molecule (Raph blood group)
CD59 CD59 molecule, complement regulatory protein
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CKAP4 cytoskeleton-associated protein 4
COL1A2 collagen, type I, alpha 2
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDHD2 DDHD domain containing 2
DHCR24 24-dehydrocholesterol reductase
EHBP1 EH domain binding protein 1
EHD2 EH-domain containing 2
EMP3 epithelial membrane protein 3
EREG epiregulin
ERLIN1 ER lipid raft associated 1
ERLIN2 ER lipid raft associated 2
EXTL2 exostosin-like glycosyltransferase 2
FAM3C family with sequence similarity 3, member C
FBN1 fibrillin 1
FGG fibrinogen gamma chain
FLNA filamin A, alpha
FLNB filamin B, beta
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GPSM2 G-protein signaling modulator 2
GRB10 growth factor receptor-bound protein 10
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HLTF helicase-like transcription factor
HN1L hematological and neurological expressed 1-like
HSPG2 heparan sulfate proteoglycan 2
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
ICMT isoprenylcysteine carboxyl methyltransferase
IFRD2 interferon-related developmental regulator 2
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KIAA1033 KIAA1033
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KRT7 keratin 7, type II
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MARCKS myristoylated alanine-rich protein kinase C substrate
MSMO1 methylsterol monooxygenase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYOF myoferlin
NEFH neurofilament, heavy polypeptide
NEK2 NIMA-related kinase 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NREP neuronal regeneration related protein
NRP1 neuropilin 1
OPN3 opsin 3
PBK PDZ binding kinase
PBX1 pre-B-cell leukemia homeobox 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFC platelet derived growth factor C
PDLIM2 PDZ and LIM domain 2 (mystique)
PEX11A peroxisomal biogenesis factor 11 alpha
PFAS phosphoribosylformylglycinamidine synthase
PLK1 polo-like kinase 1
PLS3 plastin 3
PNMA2 paraneoplastic Ma antigen 2
PON2 paraoxonase 2
POSTN periostin, osteoblast specific factor
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRSS23 protease, serine, 23
PSD3 pleckstrin and Sec7 domain containing 3
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTP4A2 protein tyrosine phosphatase type IVA, member 2
QDPR quinoid dihydropteridine reductase
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUFY3 RUN and FYVE domain containing 3
RUVBL1 RuvB-like AAA ATPase 1
SCARB2 scavenger receptor class B, member 2
SCG5 secretogranin V
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPT10 septin 10
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SMAD3 SMAD family member 3
SNAP25 synaptosomal-associated protein, 25kDa
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRPX sushi-repeat containing protein, X-linked
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TM4SF1 transmembrane 4 L six family member 1
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TPCN1 two pore segment channel 1
TSPAN3 tetraspanin 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WWTR1 WW domain containing transcription regulator 1