BRD-A24396574_celastrol_HS578T_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

181 genes differentially expressed following the BRD-A24396574_celastrol_HS578T_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACSL5 acyl-CoA synthetase long-chain family member 5
ADIRF adipogenesis regulatory factor
AKR1C3 aldo-keto reductase family 1, member C3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMIGO2 adhesion molecule with Ig-like domain 2
ANGPTL2 angiopoietin-like 2
ANK2 ankyrin 2, neuronal
AQP3 aquaporin 3 (Gill blood group)
ARL4A ADP-ribosylation factor-like 4A
ARRB2 arrestin, beta 2
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BLNK B-cell linker
BTG2 BTG family, member 2
C1ORF106 chromosome 1 open reading frame 106
C5AR1 complement component 5a receptor 1
CCL13 chemokine (C-C motif) ligand 13
CCR2 chemokine (C-C motif) receptor 2
CD14 CD14 molecule
CD9 CD9 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CKLF chemokine-like factor
CNPY3 canopy FGF signaling regulator 3
CPB1 carboxypeptidase B1 (tissue)
CTGF connective tissue growth factor
CTSS cathepsin S
CXADR coxsackie virus and adenovirus receptor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DEPTOR DEP domain containing MTOR-interacting protein
DNM3 dynamin 3
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
E2F2 E2F transcription factor 2
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EMX2 empty spiracles homeobox 2
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPCAM epithelial cell adhesion molecule
ERBB4 erb-b2 receptor tyrosine kinase 4
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EXPH5 exophilin 5
F13A1 coagulation factor XIII, A1 polypeptide
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FERMT1 fermitin family member 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FRZB frizzled-related protein
G0S2 G0/G1 switch 2
GAB2 GRB2-associated binding protein 2
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GDF15 growth differentiation factor 15
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GRB14 growth factor receptor-bound protein 14
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXD1 homeobox D1
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IL13RA2 interleukin 13 receptor, alpha 2
IL1B interleukin 1, beta
IL6 interleukin 6
ITM2C integral membrane protein 2C
KLF5 Kruppel-like factor 5 (intestinal)
KRT19 keratin 19, type I
KRT20 keratin 20, type I
KRT23 keratin 23, type I
LGALS4 lectin, galactoside-binding, soluble, 4
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1C1 mannosidase, alpha, class 1C, member 1
MANSC1 MANSC domain containing 1
MAP7 microtubule-associated protein 7
MEF2C myocyte enhancer factor 2C
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MYH11 myosin, heavy chain 11, smooth muscle
NCF2 neutrophil cytosolic factor 2
NMU neuromedin U
NOX4 NADPH oxidase 4
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
ODC1 ornithine decarboxylase 1
OLFM4 olfactomedin 4
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PERP PERP, TP53 apoptosis effector
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLBD1 phospholipase B domain containing 1
PLCL2 phospholipase C-like 2
PLLP plasmolipin
PLS1 plastin 1
PRKCQ protein kinase C, theta
PRR15L proline rich 15-like
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPN3 protein tyrosine phosphatase, non-receptor type 3
QPCT glutaminyl-peptide cyclotransferase
REG1B regenerating islet-derived 1 beta
RGCC regulator of cell cycle
RHOBTB3 Rho-related BTB domain containing 3
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SLC38A1 solute carrier family 38, member 1
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SSBP2 single-stranded DNA binding protein 2
TBX2 T-box 2
TFPI2 tissue factor pathway inhibitor 2
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN7 tetraspanin 7
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGT8 UDP glycosyltransferase 8
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VAV3 vav 3 guanine nucleotide exchange factor
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VNN1 vanin 1
VSIG4 V-set and immunoglobulin domain containing 4
XIST X inactive specific transcript (non-protein coding)
ZDHHC11 zinc finger, DHHC-type containing 11
ZFPM2 zinc finger protein, FOG family member 2
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
ADAM9 ADAM metallopeptidase domain 9
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALCAM activated leukocyte cell adhesion molecule
ARHGAP29 Rho GTPase activating protein 29
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
CAB39 calcium binding protein 39
CENPF centromere protein F, 350/400kDa
CHSY1 chondroitin sulfate synthase 1
CLU clusterin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
FLNB filamin B, beta
FSTL1 follistatin-like 1
GAS1 growth arrest-specific 1
IL6ST interleukin 6 signal transducer
KCTD3 potassium channel tetramerization domain containing 3
KIAA1033 KIAA1033
KIF1B kinesin family member 1B
LAMC1 laminin, gamma 1 (formerly LAMB2)
LBR lamin B receptor
LRRC41 leucine rich repeat containing 41
MACF1 microtubule-actin crosslinking factor 1
MYH10 myosin, heavy chain 10, non-muscle
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OPN3 opsin 3
PCM1 pericentriolar material 1
PDLIM5 PDZ and LIM domain 5
PEX11A peroxisomal biogenesis factor 11 alpha
PGC progastricsin (pepsinogen C)
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
S100A7 S100 calcium binding protein A7
SEC23A Sec23 homolog A (S. cerevisiae)
SEC24A SEC24 family member A
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SOAT1 sterol O-acyltransferase 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TMED5 transmembrane emp24 protein transport domain containing 5
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TUBB6 tubulin, beta 6 class V
WWTR1 WW domain containing transcription regulator 1