BRD-A24396574_celastrol_HME1_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-A24396574_celastrol_HME1_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
FBLN1 fibulin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GDF15 growth differentiation factor 15
HBB hemoglobin, beta
HSPA1A heat shock 70kDa protein 1A
IER2 immediate early response 2
IGFBP6 insulin-like growth factor binding protein 6
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MB myoglobin
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PEG10 paternally expressed 10
PLAC8 placenta-specific 8
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
AMIGO2 adhesion molecule with Ig-like domain 2
BGN biglycan
BHLHE41 basic helix-loop-helix family, member e41
C5ORF30 chromosome 5 open reading frame 30
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDV3 CDV3 homolog (mouse)
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTSV cathepsin V
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DCK deoxycytidine kinase
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15
DUSP14 dual specificity phosphatase 14
ELL2 elongation factor, RNA polymerase II, 2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GLIPR1 GLI pathogenesis-related 1
HMOX1 heme oxygenase 1
HOXC10 homeobox C10
ICAM1 intercellular adhesion molecule 1
INHBA inhibin, beta A
ITGAV integrin, alpha V
KRAS Kirsten rat sarcoma viral oncogene homolog
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LTBP2 latent transforming growth factor beta binding protein 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MEX3C mex-3 RNA binding family member C
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP9 matrix metallopeptidase 9
NET1 neuroepithelial cell transforming 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NRIP1 nuclear receptor interacting protein 1
PCDH7 protocadherin 7
PDGFA platelet-derived growth factor alpha polypeptide
PPIF peptidylprolyl isomerase F
RBM3 RNA binding motif (RNP1, RRM) protein 3
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
SDC4 syndecan 4
SMAD7 SMAD family member 7
SNAP25 synaptosomal-associated protein, 25kDa
SPHK1 sphingosine kinase 1
TACSTD2 tumor-associated calcium signal transducer 2
THBS1 thrombospondin 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPM4 tropomyosin 4
UBA6 ubiquitin-like modifier activating enzyme 6
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UFM1 ubiquitin-fold modifier 1
UGDH UDP-glucose 6-dehydrogenase
VCAM1 vascular cell adhesion molecule 1
WT1 Wilms tumor 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1