BRD-A24396574_celastrol_HME1_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

134 genes differentially expressed following the BRD-A24396574_celastrol_HME1_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
APOLD1 apolipoprotein L domain containing 1
ARID4B AT rich interactive domain 4B (RBP1-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
BTG2 BTG family, member 2
C9ORF3 chromosome 9 open reading frame 3
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHEK2 checkpoint kinase 2
CSRP2 cysteine and glycine-rich protein 2
CTH cystathionine gamma-lyase
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
FBLN1 fibulin 1
FLRT3 fibronectin leucine rich transmembrane protein 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GLUL glutamate-ammonia ligase
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IER2 immediate early response 2
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
JMJD6 jumonji domain containing 6
JUNB jun B proto-oncogene
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
LPAR1 lysophosphatidic acid receptor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MCL1 myeloid cell leukemia 1
MECOM MDS1 and EVI1 complex locus
MEIS1 Meis homeobox 1
MTUS1 microtubule associated tumor suppressor 1
NEFM neurofilament, medium polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PAN2 PAN2 poly(A) specific ribonuclease subunit
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
S100P S100 calcium binding protein P
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A2 solute carrier family 38, member 2
TBX2 T-box 2
TFRC transferrin receptor
TOB1 transducer of ERBB2, 1
TSC22D3 TSC22 domain family, member 3
TWIST1 twist family bHLH transcription factor 1
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
AKAP12 A kinase (PRKA) anchor protein 12
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AZU1 azurocidin 1
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CELF2 CUGBP, Elav-like family member 2
CFB complement factor B
CP ceruloplasmin (ferroxidase)
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL8 chemokine (C-X-C motif) ligand 8
DEFB1 defensin, beta 1
DPP4 dipeptidyl-peptidase 4
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
EMP3 epithelial membrane protein 3
ENO1 enolase 1, (alpha)
FOLR1 folate receptor 1 (adult)
GPX1 glutathione peroxidase 1
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
ICAM1 intercellular adhesion molecule 1
IFI27 interferon, alpha-inducible protein 27
LAPTM4B lysosomal protein transmembrane 4 beta
MN1 meningioma (disrupted in balanced translocation) 1
NT5E 5'-nucleotidase, ecto (CD73)
OPTN optineurin
PDZK1IP1 PDZK1 interacting protein 1
PTGIS prostaglandin I2 (prostacyclin) synthase
RBM3 RNA binding motif (RNP1, RRM) protein 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100A7 S100 calcium binding protein A7
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SPP1 secreted phosphoprotein 1
TF transferrin
TFPI2 tissue factor pathway inhibitor 2
TMEM45A transmembrane protein 45A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)