BRD-A24396574_celastrol_HME1_3_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-A24396574_celastrol_HME1_3_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRE5 adhesion G protein-coupled receptor E5
ADGRL2 adhesion G protein-coupled receptor L2
ATF3 activating transcription factor 3
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BHLHE40 basic helix-loop-helix family, member e40
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DOCK4 dedicator of cytokinesis 4
EFNB2 ephrin-B2
FGFR2 fibroblast growth factor receptor 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAS6 growth arrest-specific 6
GATA2 GATA binding protein 2
GEM GTP binding protein overexpressed in skeletal muscle
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IL7R interleukin 7 receptor
JMJD6 jumonji domain containing 6
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD5 potassium channel tetramerization domain containing 5
KLHL21 kelch-like family member 21
KRT19 keratin 19, type I
LCK LCK proto-oncogene, Src family tyrosine kinase
LEF1 lymphoid enhancer-binding factor 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2A1 mannosidase, alpha, class 2A, member 1
MEF2C myocyte enhancer factor 2C
NRIP1 nuclear receptor interacting protein 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PTPRC protein tyrosine phosphatase, receptor type, C
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLIT2 slit homolog 2 (Drosophila)
SMYD2 SET and MYND domain containing 2
SNAP23 synaptosomal-associated protein, 23kDa
SORBS2 sorbin and SH3 domain containing 2
TGFA transforming growth factor, alpha
TRIM2 tripartite motif containing 2
TXNRD1 thioredoxin reductase 1
XCL1 chemokine (C motif) ligand 1

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
CDH3 cadherin 3, type 1, P-cadherin (placental)
F3 coagulation factor III (thromboplastin, tissue factor)
GRB14 growth factor receptor-bound protein 14
H3F3B H3 histone, family 3B (H3.3B)
HOOK2 hook microtubule-tethering protein 2
ICAM1 intercellular adhesion molecule 1
IGFBP5 insulin-like growth factor binding protein 5
IL1B interleukin 1, beta
ITGB6 integrin, beta 6
JADE2 jade family PHD finger 2
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MATN2 matrilin 2
MBP myelin basic protein
PLK1 polo-like kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLP1 proteolipid protein 1
PNMA2 paraneoplastic Ma antigen 2
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RAD51C RAD51 paralog C
RCAN1 regulator of calcineurin 1
S100B S100 calcium binding protein B
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRI sorcin
SRPX sushi-repeat containing protein, X-linked
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TXNIP thioredoxin interacting protein
ZDHHC11 zinc finger, DHHC-type containing 11