BRD-A24396574_celastrol_HME1_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-A24396574_celastrol_HME1_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACLY ATP citrate lyase
ADGRE5 adhesion G protein-coupled receptor E5
ANKRD11 ankyrin repeat domain 11
ATF3 activating transcription factor 3
AUTS2 autism susceptibility candidate 2
BAG3 BCL2-associated athanogene 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COBL cordon-bleu WH2 repeat protein
DDIT3 DNA-damage-inducible transcript 3
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP2 dual specificity phosphatase 2
EIF5A eukaryotic translation initiation factor 5A
FOLR1 folate receptor 1 (adult)
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP3 glucuronidase, beta pseudogene 3
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IGHM immunoglobulin heavy constant mu
JMJD6 jumonji domain containing 6
KLHL21 kelch-like family member 21
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LOC100272216 uncharacterized LOC100272216
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
ODC1 ornithine decarboxylase 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SPEN spen family transcriptional repressor
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
WT1 Wilms tumor 1

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ANPEP alanyl (membrane) aminopeptidase
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BHLHE41 basic helix-loop-helix family, member e41
BMP2 bone morphogenetic protein 2
CCL20 chemokine (C-C motif) ligand 20
CD36 CD36 molecule (thrombospondin receptor)
CD59 CD59 molecule, complement regulatory protein
CXCL14 chemokine (C-X-C motif) ligand 14
CYTL1 cytokine-like 1
FABP7 fatty acid binding protein 7, brain
FAM3C family with sequence similarity 3, member C
GLS glutaminase
HOOK2 hook microtubule-tethering protein 2
IGFBP7 insulin-like growth factor binding protein 7
IL1B interleukin 1, beta
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT81 keratin 81, type II
LYPLA1 lysophospholipase I
MARCKS myristoylated alanine-rich protein kinase C substrate
NRN1 neuritin 1
POSTN periostin, osteoblast specific factor
PTGES prostaglandin E synthase
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
S100A8 S100 calcium binding protein A8
SDC1 syndecan 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SPP1 secreted phosphoprotein 1
SRPX sushi-repeat containing protein, X-linked
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM45A transmembrane protein 45A
TNC tenascin C
TSC22D3 TSC22 domain family, member 3