BRD-A24396574_celastrol_HME1_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

153 genes differentially expressed following the BRD-A24396574_celastrol_HME1_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACKR3 atypical chemokine receptor 3
ADAMDEC1 ADAM-like, decysin 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ASRGL1 asparaginase like 1
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BTG2 BTG family, member 2
CCL20 chemokine (C-C motif) ligand 20
CD1E CD1e molecule
CD4 CD4 molecule
CD44 CD44 molecule (Indian blood group)
CD84 CD84 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC7A C-type lectin domain family 7, member A
CLU clusterin
COL3A1 collagen, type III, alpha 1
CRABP1 cellular retinoic acid binding protein 1
CTAG2 cancer/testis antigen 2
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DLX2 distal-less homeobox 2
DMD dystrophin
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DUSP2 dual specificity phosphatase 2
E2F2 E2F transcription factor 2
EPHB2 EPH receptor B2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP1 fatty acid binding protein 1, liver
FGL2 fibrinogen-like 2
FGR FGR proto-oncogene, Src family tyrosine kinase
FTH1 ferritin, heavy polypeptide 1
GAP43 growth associated protein 43
GPNMB glycoprotein (transmembrane) nmb
GSE1 Gse1 coiled-coil protein
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HRG histidine-rich glycoprotein
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL15 interleukin 15
IL20RA interleukin 20 receptor, alpha
ITFG1 integrin alpha FG-GAP repeat containing 1
ITM2A integral membrane protein 2A
KDM5B lysine (K)-specific demethylase 5B
KRT13 keratin 13, type I
LEFTY1 left-right determination factor 1
LRRC17 leucine rich repeat containing 17
MEF2C myocyte enhancer factor 2C
METTL7A methyltransferase like 7A
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP12 matrix metallopeptidase 12
NAP1L3 nucleosome assembly protein 1-like 3
NGRN neugrin, neurite outgrowth associated
NOD2 nucleotide-binding oligomerization domain containing 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OVGP1 oviductal glycoprotein 1, 120kDa
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PDE1A phosphodiesterase 1A, calmodulin-dependent
PERP PERP, TP53 apoptosis effector
PEX11A peroxisomal biogenesis factor 11 alpha
PPAP2B phosphatidic acid phosphatase type 2B
PTCH1 patched 1
PTPRD protein tyrosine phosphatase, receptor type, D
RAB25 RAB25, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RGS5 regulator of G-protein signaling 5
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
S100A7 S100 calcium binding protein A7
SDC2 syndecan 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SH2D1A SH2 domain containing 1A
SNCA synuclein, alpha (non A4 component of amyloid precursor)
ST18 suppression of tumorigenicity 18, zinc finger
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TDO2 tryptophan 2,3-dioxygenase
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TLR4 toll-like receptor 4
TOX thymocyte selection-associated high mobility group box
TSHR thyroid stimulating hormone receptor
TSPAN7 tetraspanin 7
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VNN1 vanin 1
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AGTR1 angiotensin II receptor, type 1
ALCAM activated leukocyte cell adhesion molecule
ANXA3 annexin A3
ANXA5 annexin A5
ARHGAP29 Rho GTPase activating protein 29
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BST2 bone marrow stromal cell antigen 2
CA2 carbonic anhydrase II
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCND1 cyclin D1
CD59 CD59 molecule, complement regulatory protein
CD63 CD63 molecule
CDC42 cell division cycle 42
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLTC clathrin, heavy chain (Hc)
CNN3 calponin 3, acidic
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
FLNA filamin A, alpha
FLRT3 fibronectin leucine rich transmembrane protein 3
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GNAS GNAS complex locus
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KRT7 keratin 7, type II
LAMC1 laminin, gamma 1 (formerly LAMB2)
LBR lamin B receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LTF lactotransferrin
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MEST mesoderm specific transcript
MMP7 matrix metallopeptidase 7
NPY1R neuropeptide Y receptor Y1
P4HB prolyl 4-hydroxylase, beta polypeptide
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKCA protein kinase C, alpha
PSD3 pleckstrin and Sec7 domain containing 3
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PXDN peroxidasin
RHOA ras homolog family member A
RHOC ras homolog family member C
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN13 tetraspanin 13
TUBA4A tubulin, alpha 4a
TUBB tubulin, beta class I
TUBB6 tubulin, beta 6 class V
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1