BRD-A24396574_celastrol_HME1_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

255 genes differentially expressed following the BRD-A24396574_celastrol_HME1_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ARID4B AT rich interactive domain 4B (RBP1-like)
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BTG1 B-cell translocation gene 1, anti-proliferative
C2ORF49 chromosome 2 open reading frame 49
CA1 carbonic anhydrase I
CADM1 cell adhesion molecule 1
CCNL1 cyclin L1
CD24 CD24 molecule
CD4 CD4 molecule
CDC25A cell division cycle 25A
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHIC2 cysteine-rich hydrophobic domain 2
CHMP1B charged multivesicular body protein 1B
CLDN3 claudin 3
CRABP1 cellular retinoic acid binding protein 1
CRYAB crystallin, alpha B
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FASTKD5 FAST kinase domains 5
FAXDC2 fatty acid hydroxylase domain containing 2
FGL2 fibrinogen-like 2
FKBP14 FK506 binding protein 14, 22 kDa
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
GAB2 GRB2-associated binding protein 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GNAS GNAS complex locus
GOLT1B golgi transport 1B
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IFRD1 interferon-related developmental regulator 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL10RA interleukin 10 receptor, alpha
IL17RB interleukin 17 receptor B
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD6 jumonji domain containing 6
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
LBH limb bud and heart development
LCN2 lipocalin 2
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MIR22HG MIR22 host gene
MKRN1 makorin ring finger protein 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSX1 msh homeobox 1
MXI1 MAX interactor 1, dimerization protein
NEFL neurofilament, light polypeptide
NEFM neurofilament, medium polypeptide
NEU1 sialidase 1 (lysosomal sialidase)
NGRN neugrin, neurite outgrowth associated
NOD2 nucleotide-binding oligomerization domain containing 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
OSER1 oxidative stress responsive serine-rich 1
PCP4 Purkinje cell protein 4
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PELI1 pellino E3 ubiquitin protein ligase 1
PHGDH phosphoglycerate dehydrogenase
PLCB4 phospholipase C, beta 4
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTPRD protein tyrosine phosphatase, receptor type, D
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB29 RAB29, member RAS oncogene family
RB1CC1 RB1-inducible coiled-coil 1
REG1A regenerating islet-derived 1 alpha
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
RNMT RNA (guanine-7-) methyltransferase
RRAGD Ras-related GTP binding D
SAT1 spermidine/spermine N1-acetyltransferase 1
SATB2 SATB homeobox 2
SCGB1D2 secretoglobin, family 1D, member 2
SDC2 syndecan 2
SEC24A SEC24 family member A
SEC61B Sec61 beta subunit
SERINC5 serine incorporator 5
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SIK3 SIK family kinase 3
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMIM7 small integral membrane protein 7
SQSTM1 sequestosome 1
SST somatostatin
STK38L serine/threonine kinase 38 like
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM176B transmembrane protein 176B
TMEM45A transmembrane protein 45A
TRIM36 tripartite motif containing 36
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
TYROBP TYRO protein tyrosine kinase binding protein
WT1 Wilms tumor 1
ZC3H11A zinc finger CCCH-type containing 11A
ZFAND5 zinc finger, AN1-type domain 5
ZNF394 zinc finger protein 394
ZNF426 zinc finger protein 426
ZNF430 zinc finger protein 430
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ADIRF adipogenesis regulatory factor
AGTR1 angiotensin II receptor, type 1
AHNAK2 AHNAK nucleoprotein 2
ANXA3 annexin A3
ANXA4 annexin A4
ANXA7 annexin A7
APEH acylaminoacyl-peptide hydrolase
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPH aspartate beta-hydroxylase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B3GNT1
C1ORF116 chromosome 1 open reading frame 116
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CBFB core-binding factor, beta subunit
CCBL2 cysteine conjugate-beta lyase 2
CCNA2 cyclin A2
CCND1 cyclin D1
CD59 CD59 molecule, complement regulatory protein
CDC20 cell division cycle 20
CDC42 cell division cycle 42
DDB2 damage-specific DNA binding protein 2, 48kDa
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYD dihydropyrimidine dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
EBP emopamil binding protein (sterol isomerase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ETV1 ets variant 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM3C family with sequence similarity 3, member C
FASN fatty acid synthase
FGG fibrinogen gamma chain
FSTL1 follistatin-like 1
GPSM2 G-protein signaling modulator 2
HMGA2 high mobility group AT-hook 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICMT isoprenylcysteine carboxyl methyltransferase
IGFBP6 insulin-like growth factor binding protein 6
IL1B interleukin 1, beta
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS1 lectin, galactoside-binding, soluble, 1
LOXL2 lysyl oxidase-like 2
LUM lumican
MBOAT2 membrane bound O-acyltransferase domain containing 2
MET MET proto-oncogene, receptor tyrosine kinase
MMP7 matrix metallopeptidase 7
MRPL12 mitochondrial ribosomal protein L12
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYOF myoferlin
NNMT nicotinamide N-methyltransferase
NPY1R neuropeptide Y receptor Y1
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
PCNA proliferating cell nuclear antigen
PDGFC platelet derived growth factor C
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAU plasminogen activator, urokinase
PLK1 polo-like kinase 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PON2 paraoxonase 2
POSTN periostin, osteoblast specific factor
PPA2 pyrophosphatase (inorganic) 2
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRMT1 protein arginine methyltransferase 1
PRSS23 protease, serine, 23
PSD3 pleckstrin and Sec7 domain containing 3
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PXDN peroxidasin
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RPA3 replication protein A3, 14kDa
RRM2 ribonucleotide reductase M2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDC1 syndecan 1
SEPT11 septin 11
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMC1A structural maintenance of chromosomes 1A
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SQRDL sulfide quinone reductase-like (yeast)
SRI sorcin
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN2 transgelin 2
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRAM2 translocation associated membrane protein 2
TSPAN3 tetraspanin 3
TSPAN4 tetraspanin 4
TUBB tubulin, beta class I
ZNF185 zinc finger protein 185 (LIM domain)