BRD-A24396574_celastrol_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-A24396574_celastrol_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRL2 adhesion G protein-coupled receptor L2
CDK19 cyclin-dependent kinase 19
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN10 claudin 10
DSP desmoplakin
EDNRB endothelin receptor type B
GJA1 gap junction protein, alpha 1, 43kDa
GREM1 gremlin 1, DAN family BMP antagonist
GULP1 GULP, engulfment adaptor PTB domain containing 1
HOMER1 homer scaffolding protein 1
IL6 interleukin 6
KRT15 keratin 15, type I
KRT5 keratin 5, type II
LEF1 lymphoid enhancer-binding factor 1
MME membrane metallo-endopeptidase
MT2A metallothionein 2A
NR4A2 nuclear receptor subfamily 4, group A, member 2
NXN nucleoredoxin
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
RGS4 regulator of G-protein signaling 4
SATB1 SATB homeobox 1
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TNC tenascin C
TPP1 tripeptidyl peptidase I
TRIB2 tribbles pseudokinase 2
TXNRD1 thioredoxin reductase 1
WT1 Wilms tumor 1

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ACOT9 acyl-CoA thioesterase 9
ACTA1 actin, alpha 1, skeletal muscle
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ANXA4 annexin A4
ANXA6 annexin A6
BMP2 bone morphogenetic protein 2
CD99 CD99 molecule
CKAP4 cytoskeleton-associated protein 4
CLMN calmin (calponin-like, transmembrane)
DAPK1 death-associated protein kinase 1
DHCR24 24-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGFR4 fibroblast growth factor receptor 4
FLRT3 fibronectin leucine rich transmembrane protein 3
FOLR1 folate receptor 1 (adult)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPC3 glypican 3
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNMT histamine N-methyltransferase
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI6 interferon, alpha-inducible protein 6
MCAM melanoma cell adhesion molecule
MTSS1 metastasis suppressor 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PLXNA2 plexin A2
PPARG peroxisome proliferator-activated receptor gamma
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTP4A2 protein tyrosine phosphatase type IVA, member 2
QPRT quinolinate phosphoribosyltransferase
SFRP4 secreted frizzled-related protein 4
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNX11 sorting nexin 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SQLE squalene epoxidase
TESC tescalcin
TNNC1 troponin C type 1 (slow)
TNNT1 troponin T type 1 (skeletal, slow)
TOX3 TOX high mobility group box family member 3
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28