BRD-A24396574_celastrol_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

214 genes differentially expressed following the BRD-A24396574_celastrol_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACSL1 acyl-CoA synthetase long-chain family member 1
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AMDHD2 amidohydrolase domain containing 2
ANKRD12 ankyrin repeat domain 12
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BEX1 brain expressed, X-linked 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C5AR1 complement component 5a receptor 1
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHMP1B charged multivesicular body protein 1B
COL11A1 collagen, type XI, alpha 1
CTSA cathepsin A
CTSD cathepsin D
CTSL cathepsin L
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNASE2 deoxyribonuclease II, lysosomal
DPP4 dipeptidyl-peptidase 4
DUSP1 dual specificity phosphatase 1
ELL2 elongation factor, RNA polymerase II, 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F13A1 coagulation factor XIII, A1 polypeptide
FAM46A family with sequence similarity 46, member A
FOSL1 FOS-like antigen 1
FOXO4 forkhead box O4
G6PD glucose-6-phosphate dehydrogenase
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA3 GATA binding protein 3
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GLRX glutaredoxin (thioltransferase)
GNPDA1 glucosamine-6-phosphate deaminase 1
GNS glucosamine (N-acetyl)-6-sulfatase
GSTT1 glutathione S-transferase theta 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ICAM1 intercellular adhesion molecule 1
IDE insulin-degrading enzyme
IGKV1-5 immunoglobulin kappa variable 1-5
IL6 interleukin 6
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLHL24 kelch-like family member 24
LAMP2 lysosomal-associated membrane protein 2
LGALS8 lectin, galactoside-binding, soluble, 8
LOX lysyl oxidase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCOLN1 mucolipin 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MERTK MER proto-oncogene, tyrosine kinase
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOSPD1 motile sperm domain containing 1
MXI1 MAX interactor 1, dimerization protein
MYO6 myosin VI
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHYH phytanoyl-CoA 2-hydroxylase
PIR pirin (iron-binding nuclear protein)
PLA2G16 phospholipase A2, group XVI
PLIN2 perilipin 2
RAB29 RAB29, member RAS oncogene family
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF114 ring finger protein 114
RRAGD Ras-related GTP binding D
SAT1 spermidine/spermine N1-acetyltransferase 1
SEC24A SEC24 family member A
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAP1 small ArfGAP 1
SOWAHC sosondowah ankyrin repeat domain family member C
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
TBX3 T-box 3
TFE3 transcription factor binding to IGHM enhancer 3
TIMP3 TIMP metallopeptidase inhibitor 3
TPP1 tripeptidyl peptidase I
TUBB2A tubulin, beta 2A class IIa
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAT1 vesicle amine transport 1
WBP5 WW domain binding protein 5
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ARL4C ADP-ribosylation factor-like 4C
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
CAV1 caveolin 1, caveolae protein, 22kDa
CCK cholecystokinin
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CDK1 cyclin-dependent kinase 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CERK ceramide kinase
CFH complement factor H
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
DEPTOR DEP domain containing MTOR-interacting protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYSL2 dihydropyrimidinase-like 2
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
ECT2 epithelial cell transforming 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPER1 G protein-coupled estrogen receptor 1
GTSE1 G-2 and S-phase expressed 1
HELLS helicase, lymphoid-specific
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA8 heat shock 70kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF18B kinesin family member 18B
KRT19 keratin 19, type I
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MKI67 marker of proliferation Ki-67
MLPH melanophilin
MUC16 mucin 16, cell surface associated
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEK2 NIMA-related kinase 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUSAP1 nucleolar and spindle associated protein 1
OLFM1 olfactomedin 1
PCNA proliferating cell nuclear antigen
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSPH phosphoserine phosphatase
RACGAP1 Rac GTPase activating protein 1
RBP1 retinol binding protein 1, cellular
RFC3 replication factor C (activator 1) 3, 38kDa
RFTN1 raftlin, lipid raft linker 1
RRM2 ribonucleotide reductase M2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SORD sorbitol dehydrogenase
SPON1 spondin 1, extracellular matrix protein
SRSF7 serine/arginine-rich splicing factor 7
SSBP2 single-stranded DNA binding protein 2
SULF1 sulfatase 1
TCF3 transcription factor 3
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMELESS timeless circadian clock
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TRIB2 tribbles pseudokinase 2
TRIP13 thyroid hormone receptor interactor 13
TUBB tubulin, beta class I
TYMS thymidylate synthetase
USP1 ubiquitin specific peptidase 1
VCAN versican
VRK1 vaccinia related kinase 1
WRB tryptophan rich basic protein
ZWINT ZW10 interacting kinetochore protein