BRD-A24396574_celastrol_HCC515_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

186 genes differentially expressed following the BRD-A24396574_celastrol_HCC515_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
APOLD1 apolipoprotein L domain containing 1
ARID4B AT rich interactive domain 4B (RBP1-like)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BCL3 B-cell CLL/lymphoma 3
BIK BCL2-interacting killer (apoptosis-inducing)
BRD2 bromodomain containing 2
BTG2 BTG family, member 2
C21ORF91 chromosome 21 open reading frame 91
CCL5 chemokine (C-C motif) ligand 5
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CH25H cholesterol 25-hydroxylase
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHODL chondrolectin
CRABP1 cellular retinoic acid binding protein 1
CTGF connective tissue growth factor
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL2 chemokine (C-X-C motif) ligand 2
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DACH1 dachshund family transcription factor 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EPHA3 EPH receptor A3
EZR ezrin
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FRZB frizzled-related protein
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IER5 immediate early response 5
IGFBP7 insulin-like growth factor binding protein 7
JMJD6 jumonji domain containing 6
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KTN1 kinectin 1 (kinesin receptor)
LEFTY1 left-right determination factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MT1F metallothionein 1F
MT1X metallothionein 1X
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
ODC1 ornithine decarboxylase 1
PER2 period circadian clock 2
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKCD protein kinase C, delta
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RHOB ras homolog family member B
RPP38 ribonuclease P/MRP 38kDa subunit
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SELE selectin E
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SOX9 SRY (sex determining region Y)-box 9
SRRM2 serine/arginine repetitive matrix 2
STC1 stanniocalcin 1
TACC2 transforming, acidic coiled-coil containing protein 2
TICAM1 toll-like receptor adaptor molecule 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TNPO1 transportin 1
TOB2 transducer of ERBB2, 2
TSPAN4 tetraspanin 4
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAM1 vascular cell adhesion molecule 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ABHD2 abhydrolase domain containing 2
ADAM10 ADAM metallopeptidase domain 10
ADCY1 adenylate cyclase 1 (brain)
ADGRG6 adhesion G protein-coupled receptor G6
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALOX5 arachidonate 5-lipoxygenase
APOH apolipoprotein H (beta-2-glycoprotein I)
ARHGAP29 Rho GTPase activating protein 29
ASCC3 activating signal cointegrator 1 complex subunit 3
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BICC1 BicC family RNA binding protein 1
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CALU calumenin
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPE centromere protein E, 312kDa
CLCN3 chloride channel, voltage-sensitive 3
CPD carboxypeptidase D
CPNE3 copine III
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
DAPK1 death-associated protein kinase 1
DMXL2 Dmx-like 2
DPYSL2 dihydropyrimidinase-like 2
EAPP E2F-associated phosphoprotein
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ERO1L ERO1-like (S. cerevisiae)
FABP4 fatty acid binding protein 4, adipocyte
FGG fibrinogen gamma chain
G0S2 G0/G1 switch 2
GBE1 glucan (1,4-alpha-), branching enzyme 1
HOPX HOP homeobox
JCHAIN joining chain of multimeric IgA and IgM
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KIAA1033 KIAA1033
KIF14 kinesin family member 14
KRT19 keratin 19, type I
LBR lamin B receptor
LTF lactotransferrin
MACF1 microtubule-actin crosslinking factor 1
MAN2A1 mannosidase, alpha, class 2A, member 1
MDFIC MyoD family inhibitor domain containing
MKL2 MKL/myocardin-like 2
MYH10 myosin, heavy chain 10, non-muscle
NF1 neurofibromin 1
NPY1R neuropeptide Y receptor Y1
OPN3 opsin 3
PON3 paraoxonase 3
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PRKD3 protein kinase D3
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PROS1 protein S (alpha)
PTGIS prostaglandin I2 (prostacyclin) synthase
RCAN1 regulator of calcineurin 1
RHOT1 ras homolog family member T1
RNASE4 ribonuclease, RNase A family, 4
RPA3 replication protein A3, 14kDa
SEC23A Sec23 homolog A (S. cerevisiae)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC35E2B solute carrier family 35, member E2B
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNX10 sorting nexin 10
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
THBS2 thrombospondin 2
TMX1 thioredoxin-related transmembrane protein 1
TRAM1 translocation associated membrane protein 1
TSPAN13 tetraspanin 13
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase
USP6NL USP6 N-terminal like
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
YME1L1 YME1-like 1 ATPase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta