BRD-A24396574_celastrol_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

191 genes differentially expressed following the BRD-A24396574_celastrol_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
ANO1 anoctamin 1, calcium activated chloride channel
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BLNK B-cell linker
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C21ORF59 chromosome 21 open reading frame 59
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL8 chemokine (C-C motif) ligand 8
CD163 CD163 molecule
CD200 CD200 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLCA1 chloride channel accessory 1
CLDN7 claudin 7
COL2A1 collagen, type II, alpha 1
COL3A1 collagen, type III, alpha 1
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DUSP6 dual specificity phosphatase 6
ECM1 extracellular matrix protein 1
EFNB2 ephrin-B2
EGFL6 EGF-like-domain, multiple 6
EMX2 empty spiracles homeobox 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPCAM epithelial cell adhesion molecule
ESRP1 epithelial splicing regulatory protein 1
ETHE1 ethylmalonic encephalopathy 1
F13A1 coagulation factor XIII, A1 polypeptide
FCGBP Fc fragment of IgG binding protein
FKBP1B FK506 binding protein 1B, 12.6 kDa
G0S2 G0/G1 switch 2
GGCT gamma-glutamylcyclotransferase
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRB7 growth factor receptor-bound protein 7
GSDMB gasdermin B
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGA1 high mobility group AT-hook 1
HMOX1 heme oxygenase 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IL13RA2 interleukin 13 receptor, alpha 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KRT19 keratin 19, type I
LDB2 LIM domain binding 2
LPPR4 lipid phosphate phosphatase-related protein type 4
MFAP5 microfibrillar associated protein 5
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MUC2 mucin 2, oligomeric mucus/gel-forming
PCDH17 protocadherin 17
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCLO piccolo presynaptic cytomatrix protein
PCSK1 proprotein convertase subtilisin/kexin type 1
PERP PERP, TP53 apoptosis effector
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLTP phospholipid transfer protein
PLVAP plasmalemma vesicle associated protein
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A14 S100 calcium binding protein A14
S100A8 S100 calcium binding protein A8
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SNAI2 snail family zinc finger 2
SOCS2 suppressor of cytokine signaling 2
SPARCL1 SPARC-like 1 (hevin)
SPDEF SAM pointed domain containing ETS transcription factor
SPINK4 serine peptidase inhibitor, Kazal type 4
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TMEM30B transmembrane protein 30B
TMEM70 transmembrane protein 70
TRIM2 tripartite motif containing 2
TSPAN13 tetraspanin 13
TWIST1 twist family bHLH transcription factor 1
VSIG4 V-set and immunoglobulin domain containing 4
ZG16 zymogen granule protein 16
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABHD2 abhydrolase domain containing 2
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACSL3 acyl-CoA synthetase long-chain family member 3
ACTN1 actinin, alpha 1
AK4 adenylate kinase 4
ALCAM activated leukocyte cell adhesion molecule
ANXA6 annexin A6
ARMCX2 armadillo repeat containing, X-linked 2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATXN1 ataxin 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK19 cyclin-dependent kinase 19
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSRP1 cysteine and glycine-rich protein 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DEGS1 delta(4)-desaturase, sphingolipid 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EMP3 epithelial membrane protein 3
EVL Enah/Vasp-like
FADS1 fatty acid desaturase 1
FAT1 FAT atypical cadherin 1
FKBP14 FK506 binding protein 14, 22 kDa
FLNA filamin A, alpha
FLNB filamin B, beta
FNDC3B fibronectin type III domain containing 3B
FOXO3 forkhead box O3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLIPR1 GLI pathogenesis-related 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICAM1 intercellular adhesion molecule 1
IL32 interleukin 32
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGAV integrin, alpha V
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KDM3A lysine (K)-specific demethylase 3A
LDLR low density lipoprotein receptor
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LTF lactotransferrin
MACF1 microtubule-actin crosslinking factor 1
MAGED1 melanoma antigen family D1
MAPK6 mitogen-activated protein kinase 6
MBNL1 muscleblind-like splicing regulator 1
MSMO1 methylsterol monooxygenase 1
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEK7 NIMA-related kinase 7
NNT nicotinamide nucleotide transhydrogenase
NOTCH2 notch 2
NOTCH2NL notch 2 N-terminal like
NREP neuronal regeneration related protein
PALLD palladin, cytoskeletal associated protein
PDGFC platelet derived growth factor C
PDLIM5 PDZ and LIM domain 5
PLAT plasminogen activator, tissue
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRKCA protein kinase C, alpha
RDX radixin
SACS sacsin molecular chaperone
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEC23A Sec23 homolog A (S. cerevisiae)
SFRP1 secreted frizzled-related protein 1
SQLE squalene epoxidase
SVIL supervillin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR3 transforming growth factor, beta receptor III
TGM2 transglutaminase 2
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNS1 tensin 1
TOR1AIP1 torsin A interacting protein 1
TRIM16 tripartite motif containing 16
UGCG UDP-glucose ceramide glucosyltransferase
WWTR1 WW domain containing transcription regulator 1
ZBTB18 zinc finger and BTB domain containing 18