BRD-A24396574_celastrol_HA1E_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

149 genes differentially expressed following the BRD-A24396574_celastrol_HA1E_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADGRE5 adhesion G protein-coupled receptor E5
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALAS1 5'-aminolevulinate synthase 1
ANPEP alanyl (membrane) aminopeptidase
AQP9 aquaporin 9
BTG1 B-cell translocation gene 1, anti-proliferative
C5AR1 complement component 5a receptor 1
CBR1 carbonyl reductase 1
CCND1 cyclin D1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COPA coatomer protein complex, subunit alpha
CTSD cathepsin D
CTSL cathepsin L
CYBRD1 cytochrome b reductase 1
DACH1 dachshund family transcription factor 1
DDIT3 DNA-damage-inducible transcript 3
DMBT1 deleted in malignant brain tumors 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP6 dual specificity phosphatase 6
EMC3 ER membrane protein complex subunit 3
ETV5 ets variant 5
G6PD glucose-6-phosphate dehydrogenase
GAL galanin/GMAP prepropeptide
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GPC1 glypican 1
HIST3H2A histone cluster 3, H2a
HMGA2 high mobility group AT-hook 2
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ITGA6 integrin, alpha 6
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT6B keratin 6B, type II
KYNU kynureninase
MAGEA3 melanoma antigen family A3
MCL1 myeloid cell leukemia 1
MCOLN1 mucolipin 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NARFL nuclear prelamin A recognition factor-like
NCF2 neutrophil cytosolic factor 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPC1 Niemann-Pick disease, type C1
NQO1 NAD(P)H dehydrogenase, quinone 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PDE4DIP phosphodiesterase 4D interacting protein
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLIN2 perilipin 2
RB1CC1 RB1-inducible coiled-coil 1
S100P S100 calcium binding protein P
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
SRGN serglycin
STK10 serine/threonine kinase 10
TNIK TRAF2 and NCK interacting kinase
TPP1 tripeptidyl peptidase I
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRG1 adhesion G protein-coupled receptor G1
ADRB2 adrenoceptor beta 2, surface
AQP3 aquaporin 3 (Gill blood group)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AUTS2 autism susceptibility candidate 2
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
BLNK B-cell linker
C3 complement component 3
C7 complement component 7
CAV2 caveolin 2
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CENPU centromere protein U
CFLAR CASP8 and FADD-like apoptosis regulator
CH25H cholesterol 25-hydroxylase
CSRP2 cysteine and glycine-rich protein 2
CST6 cystatin E/M
CTSH cathepsin H
CYB5A cytochrome b5 type A (microsomal)
CYTH1 cytohesin 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHA3 EPH receptor A3
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FBLN5 fibulin 5
FOLR1 folate receptor 1 (adult)
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GPX3 glutathione peroxidase 3
HILPDA hypoxia inducible lipid droplet-associated
ICAM1 intercellular adhesion molecule 1
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
LMNB1 lamin B1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTB lymphotoxin beta (TNF superfamily, member 3)
MATN2 matrilin 2
MGP matrix Gla protein
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NREP neuronal regeneration related protein
NXN nucleoredoxin
PCCB propionyl CoA carboxylase, beta polypeptide
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PXMP2 peroxisomal membrane protein 2, 22kDa
RDX radixin
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SELE selectin E
SFRP1 secreted frizzled-related protein 1
SHROOM2 shroom family member 2
SOX4 SRY (sex determining region Y)-box 4
SYNE2 spectrin repeat containing, nuclear envelope 2
TACSTD2 tumor-associated calcium signal transducer 2
TCL1A T-cell leukemia/lymphoma 1A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TSPAN6 tetraspanin 6
VCAM1 vascular cell adhesion molecule 1