BRD-A24396574_celastrol_HA1E_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

92 genes differentially expressed following the BRD-A24396574_celastrol_HA1E_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA10 annexin A10
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CNPY3 canopy FGF signaling regulator 3
CTSA cathepsin A
CYBRD1 cytochrome b reductase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
ECM1 extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
FMO3 flavin containing monooxygenase 3
GJA1 gap junction protein, alpha 1, 43kDa
GPNMB glycoprotein (transmembrane) nmb
HOXC6 homeobox C6
ICAM3 intercellular adhesion molecule 3
MYLK myosin light chain kinase
NID1 nidogen 1
NOTCH3 notch 3
PPARG peroxisome proliferator-activated receptor gamma
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRAME preferentially expressed antigen in melanoma
RRAGD Ras-related GTP binding D
SNAI2 snail family zinc finger 2
STOM stomatin
THBS2 thrombospondin 2
TWIST1 twist family bHLH transcription factor 1

decreased expression

Symbol Name
ADGRG1 adhesion G protein-coupled receptor G1
AKAP12 A kinase (PRKA) anchor protein 12
ALOX5 arachidonate 5-lipoxygenase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL2A1 BCL2-related protein A1
BHLHE41 basic helix-loop-helix family, member e41
BIK BCL2-interacting killer (apoptosis-inducing)
BIRC3 baculoviral IAP repeat containing 3
C1ORF116 chromosome 1 open reading frame 116
C3 complement component 3
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CFB complement factor B
CLU clusterin
CPA3 carboxypeptidase A3 (mast cell)
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
GATA2 GATA binding protein 2
GDF15 growth differentiation factor 15
GPX3 glutathione peroxidase 3
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
ICAM1 intercellular adhesion molecule 1
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IL32 interleukin 32
IL6 interleukin 6
JADE2 jade family PHD finger 2
KCTD12 potassium channel tetramerization domain containing 12
LAPTM5 lysosomal protein transmembrane 5
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTF lactotransferrin
LXN latexin
LYZ lysozyme
NBL1 neuroblastoma 1, DAN family BMP antagonist
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NPDC1 neural proliferation, differentiation and control, 1
PDZK1IP1 PDZK1 interacting protein 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PPL periplakin
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SYNGR2 synaptogyrin 2
TM4SF1 transmembrane 4 L six family member 1
TMEM100 transmembrane protein 100
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPSAB1 tryptase alpha/beta 1
VAMP8 vesicle-associated membrane protein 8
VCAM1 vascular cell adhesion molecule 1
VDAC1 voltage-dependent anion channel 1
WWC1 WW and C2 domain containing 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF91 zinc finger protein 91