BRD-A24396574_celastrol_BT20_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

66 genes differentially expressed following the BRD-A24396574_celastrol_BT20_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CH25H cholesterol 25-hydroxylase
COL14A1 collagen, type XIV, alpha 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTH cystathionine gamma-lyase
CYR61 cysteine-rich, angiogenic inducer, 61
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FHL1 four and a half LIM domains 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FZD5 frizzled class receptor 5
GADD45A growth arrest and DNA-damage-inducible, alpha
HBB hemoglobin, beta
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFITM1 interferon induced transmembrane protein 1
KAT6B K(lysine) acetyltransferase 6B
KDM3A lysine (K)-specific demethylase 3A
KLF2 Kruppel-like factor 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEB nebulin
NELL2 NEL-like 2 (chicken)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
S100P S100 calcium binding protein P
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPON2 spondin 2, extracellular matrix protein
TRIB1 tribbles pseudokinase 1
TUBB2A tubulin, beta 2A class IIa

decreased expression

Symbol Name
ADAMDEC1 ADAM-like, decysin 1
ALOX5 arachidonate 5-lipoxygenase
CXCL9 chemokine (C-X-C motif) ligand 9
DEFB1 defensin, beta 1
FOLR1 folate receptor 1 (adult)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HEATR1 HEAT repeat containing 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMCH1 LIM and calponin homology domains 1
NUPR1 nuclear protein, transcriptional regulator, 1
PEG10 paternally expressed 10
PSD3 pleckstrin and Sec7 domain containing 3
SCGB2A2 secretoglobin, family 2A, member 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10