BRD-A24396574_celastrol_BT20_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

171 genes differentially expressed following the BRD-A24396574_celastrol_BT20_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ACSS3 acyl-CoA synthetase short-chain family member 3
ADGRL3 adhesion G protein-coupled receptor L3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AMPH amphiphysin
ANKRD36B ankyrin repeat domain 36B
ARMCX1 armadillo repeat containing, X-linked 1
ASPN asporin
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BCL2A1 BCL2-related protein A1
BMP2 bone morphogenetic protein 2
C5AR1 complement component 5a receptor 1
CCL20 chemokine (C-C motif) ligand 20
CD177 CD177 molecule
CD320 CD320 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN1 chimerin 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CPE carboxypeptidase E
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
DUSP2 dual specificity phosphatase 2
DUSP6 dual specificity phosphatase 6
ENO2 enolase 2 (gamma, neuronal)
F13A1 coagulation factor XIII, A1 polypeptide
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FILIP1L filamin A interacting protein 1-like
G0S2 G0/G1 switch 2
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLT1B golgi transport 1B
GPNMB glycoprotein (transmembrane) nmb
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HP haptoglobin
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IGFBP3 insulin-like growth factor binding protein 3
INSR insulin receptor
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JMJD6 jumonji domain containing 6
KLF10 Kruppel-like factor 10
LMO3 LIM domain only 3 (rhombotin-like 2)
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LYZ lysozyme
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MCOLN1 mucolipin 1
MEF2C myocyte enhancer factor 2C
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP9 matrix metallopeptidase 9
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
NELL2 NEL-like 2 (chicken)
NMU neuromedin U
NREP neuronal regeneration related protein
NRN1 neuritin 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDZD2 PDZ domain containing 2
PEG3 paternally expressed 3
PHYH phytanoyl-CoA 2-hydroxylase
PLVAP plasmalemma vesicle associated protein
PTN pleiotrophin
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS4Y1 ribosomal protein S4, Y-linked 1
SAMD4A sterile alpha motif domain containing 4A
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SNX11 sorting nexin 11
SRPR signal recognition particle receptor (docking protein)
STC1 stanniocalcin 1
STK38L serine/threonine kinase 38 like
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TF transferrin
TGFB1I1 transforming growth factor beta 1 induced transcript 1
THBS4 thrombospondin 4
TM7SF2 transmembrane 7 superfamily member 2
TMEM259 transmembrane protein 259
TNC tenascin C
TNIK TRAF2 and NCK interacting kinase
TRA2A transformer 2 alpha homolog (Drosophila)
TREM1 triggering receptor expressed on myeloid cells 1
TYROBP TYRO protein tyrosine kinase binding protein
VEGFA vascular endothelial growth factor A
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
ADGRG6 adhesion G protein-coupled receptor G6
AIM1 absent in melanoma 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA7 annexin A7
ARHGAP29 Rho GTPase activating protein 29
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATMIN ATM interactor
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BICC1 BicC family RNA binding protein 1
BST2 bone marrow stromal cell antigen 2
CAB39 calcium binding protein 39
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK19 cyclin-dependent kinase 19
CENPF centromere protein F, 350/400kDa
CLTA clathrin, light chain A
CLTC clathrin, heavy chain (Hc)
COTL1 coactosin-like F-actin binding protein 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL12 chemokine (C-X-C motif) ligand 12
CYB561 cytochrome b561
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPRS glutamyl-prolyl-tRNA synthetase
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FOXO3 forkhead box O3
G6PD glucose-6-phosphate dehydrogenase
GALC galactosylceramidase
GPX2 glutathione peroxidase 2
HOXB7 homeobox B7
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGFBP4 insulin-like growth factor binding protein 4
KARS lysyl-tRNA synthetase
KAZN kazrin, periplakin interacting protein
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
LOC100505650 uncharacterized LOC100505650
LXN latexin
LY6E lymphocyte antigen 6 complex, locus E
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MMP7 matrix metallopeptidase 7
MSMB microseminoprotein, beta-
NOTCH2 notch 2
NR2F6 nuclear receptor subfamily 2, group F, member 6
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PRDX1 peroxiredoxin 1
PROM1 prominin 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RIPK4 receptor-interacting serine-threonine kinase 4
S100A7 S100 calcium binding protein A7
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SLPI secretory leukocyte peptidase inhibitor
SOX9 SRY (sex determining region Y)-box 9
TACSTD2 tumor-associated calcium signal transducer 2
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TMBIM6 transmembrane BAX inhibitor motif containing 6
TOMM34 translocase of outer mitochondrial membrane 34
TOP2A topoisomerase (DNA) II alpha 170kDa
TXNRD1 thioredoxin reductase 1
USP22 ubiquitin specific peptidase 22
VCP valosin containing protein
VGLL1 vestigial-like family member 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta