BRD-A24396574_celastrol_BT20_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

413 genes differentially expressed following the BRD-A24396574_celastrol_BT20_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AIM2 absent in melanoma 2
AKR1C2 aldo-keto reductase family 1, member C2
ARC activity-regulated cytoskeleton-associated protein
ARCN1 archain 1
ARF4 ADP-ribosylation factor 4
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BAG3 BCL2-associated athanogene 3
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCL2A1 BCL2-related protein A1
BCL6 B-cell CLL/lymphoma 6
BRD2 bromodomain containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
CACYBP calcyclin binding protein
CARS cysteinyl-tRNA synthetase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC59 coiled-coil domain containing 59
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COCH cochlin
COL3A1 collagen, type III, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
COQ10B coenzyme Q10 homolog B (S. cerevisiae)
CREM cAMP responsive element modulator
CSRP2 cysteine and glycine-rich protein 2
CTH cystathionine gamma-lyase
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYLD cylindromatosis (turban tumor syndrome)
CYTIP cytohesin 1 interacting protein
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF5 eukaryotic translation initiation factor 5
ELL2 elongation factor, RNA polymerase II, 2
EMX2 empty spiracles homeobox 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM53C family with sequence similarity 53, member C
FASTKD5 FAST kinase domains 5
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FEM1C fem-1 homolog c (C. elegans)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO4 forkhead box O4
FRS2 fibroblast growth factor receptor substrate 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GNPDA1 glucosamine-6-phosphate deaminase 1
GOLT1B golgi transport 1B
GPX7 glutathione peroxidase 7
GTF2B general transcription factor IIB
HBEGF heparin-binding EGF-like growth factor
HDGFRP3 hepatoma-derived growth factor, related protein 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IL1R2 interleukin 1 receptor, type II
IL6 interleukin 6
INHBA inhibin, beta A
IRF7 interferon regulatory factor 7
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD1C jumonji domain containing 1C
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCMF1 potassium channel modulatory factor 1
KDM3A lysine (K)-specific demethylase 3A
KDM5A lysine (K)-specific demethylase 5A
KEAP1 kelch-like ECH-associated protein 1
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
KPNA4 karyopherin alpha 4 (importin alpha 3)
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MED17 mediator complex subunit 17
MIR22HG MIR22 host gene
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP3 matrix metallopeptidase 3
MT1M metallothionein 1M
MYO10 myosin X
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NKX3-1 NK3 homeobox 1
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRBF2 nuclear receptor binding factor 2
NUPL1 nucleoporin like 1
NUPR1 nuclear protein, transcriptional regulator, 1
NXF1 nuclear RNA export factor 1
ODC1 ornithine decarboxylase 1
OSER1 oxidative stress responsive serine-rich 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCSK6 proprotein convertase subtilisin/kexin type 6
PELO pelota homolog (Drosophila)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIGA phosphatidylinositol glycan anchor biosynthesis, class A
PLAUR plasminogen activator, urokinase receptor
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2
PRNP prion protein
PTX3 pentraxin 3, long
RAB9A RAB9A, member RAS oncogene family
RAE1 ribonucleic acid export 1
RB1CC1 RB1-inducible coiled-coil 1
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
RLF rearranged L-myc fusion
RND1 Rho family GTPase 1
RNMT RNA (guanine-7-) methyltransferase
RRAGD Ras-related GTP binding D
RSRC2 arginine/serine-rich coiled-coil 2
RUNX3 runt-related transcription factor 3
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SAR1A secretion associated, Ras related GTPase 1A
SAT1 spermidine/spermine N1-acetyltransferase 1
SEC24A SEC24 family member A
SERINC1 serine incorporator 1
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SIK1 salt-inducible kinase 1
SIK3 SIK family kinase 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMCO4 single-pass membrane protein with coiled-coil domains 4
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOCS3 suppressor of cytokine signaling 3
SPAG9 sperm associated antigen 9
SPATA2 spermatogenesis associated 2
SPRY2 sprouty homolog 2 (Drosophila)
SQSTM1 sequestosome 1
SRP19 signal recognition particle 19kDa
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
STC2 stanniocalcin 2
STK17A serine/threonine kinase 17a
STK17B serine/threonine kinase 17b
STK38L serine/threonine kinase 38 like
STX3 syntaxin 3
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
THBD thrombomodulin
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSC22D1 TSC22 domain family, member 1
TSPYL2 TSPY-like 2
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
UBE2B ubiquitin-conjugating enzyme E2B
UBXN7 UBX domain protein 7
VEGFA vascular endothelial growth factor A
WBP5 WW domain binding protein 5
WDR45 WD repeat domain 45
WIF1 WNT inhibitory factor 1
XBP1 X-box binding protein 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZBTB10 zinc finger and BTB domain containing 10
ZC3H15 zinc finger CCCH-type containing 15
ZMYM5 zinc finger, MYM-type 5
ZNF165 zinc finger protein 165
ZNF394 zinc finger protein 394
ZNF473 zinc finger protein 473

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ADAM10 ADAM metallopeptidase domain 10
ADD3 adducin 3 (gamma)
ADGRG6 adhesion G protein-coupled receptor G6
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AHNAK AHNAK nucleoprotein
ALCAM activated leukocyte cell adhesion molecule
ANXA3 annexin A3
ARHGAP29 Rho GTPase activating protein 29
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C2CD2 C2 calcium-dependent domain containing 2
CALD1 caldesmon 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCNF cyclin F
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLIC3 chloride intracellular channel 3
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRABP2 cellular retinoic acid binding protein 2
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DAPK1 death-associated protein kinase 1
DHRS1 dehydrogenase/reductase (SDR family) member 1
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DMD dystrophin
DPYD dihydropyrimidine dehydrogenase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENO1 enolase 1, (alpha)
ERAP2 endoplasmic reticulum aminopeptidase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERLIN1 ER lipid raft associated 1
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
F3 coagulation factor III (thromboplastin, tissue factor)
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FCGBP Fc fragment of IgG binding protein
FHL1 four and a half LIM domains 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FMO1 flavin containing monooxygenase 1
FOXM1 forkhead box M1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAS1 growth arrest-specific 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBAS glioblastoma amplified sequence
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLDC glycine dehydrogenase (decarboxylating)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GTSE1 G-2 and S-phase expressed 1
HADH hydroxyacyl-CoA dehydrogenase
HELLS helicase, lymphoid-specific
HIST1H4C histone cluster 1, H4c
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
ICMT isoprenylcysteine carboxyl methyltransferase
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFRD2 interferon-related developmental regulator 2
IGF1R insulin-like growth factor 1 receptor
IGFBP5 insulin-like growth factor binding protein 5
IGSF3 immunoglobulin superfamily, member 3
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGB5 integrin, beta 5
JCHAIN joining chain of multimeric IgA and IgM
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF1BP KIF1 binding protein
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
LAMB1 laminin, beta 1
LAPTM4B lysosomal protein transmembrane 4 beta
LEPR leptin receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMNB2 lamin B2
LPL lipoprotein lipase
MAL mal, T-cell differentiation protein
MARCKS myristoylated alanine-rich protein kinase C substrate
MATN2 matrilin 2
MELK maternal embryonic leucine zipper kinase
METTL7A methyltransferase like 7A
MID1 midline 1
MKI67 marker of proliferation Ki-67
MKL2 MKL/myocardin-like 2
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYOF myoferlin
NADK NAD kinase
NAV2 neuron navigator 2
NCAPG2 non-SMC condensin II complex, subunit G2
NEK2 NIMA-related kinase 2
NFIB nuclear factor I/B
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUP85 nucleoporin 85kDa
NUSAP1 nucleolar and spindle associated protein 1
OPN3 opsin 3
PBK PDZ binding kinase
PBX1 pre-B-cell leukemia homeobox 1
PCCB propionyl CoA carboxylase, beta polypeptide
PDGFD platelet derived growth factor D
PDHB pyruvate dehydrogenase (lipoamide) beta
PGRMC2 progesterone receptor membrane component 2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLK1 polo-like kinase 1
PLS1 plastin 1
PPL periplakin
PRC1 protein regulator of cytokinesis 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTTG1 pituitary tumor-transforming 1
RAB31 RAB31, member RAS oncogene family
RACGAP1 Rac GTPase activating protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RNPEP arginyl aminopeptidase (aminopeptidase B)
RRM2 ribonucleotide reductase M2
RUVBL1 RuvB-like AAA ATPase 1
S100A8 S100 calcium binding protein A8
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC1 syndecan 1
SEPHS1 selenophosphate synthetase 1
SFRP1 secreted frizzled-related protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STMN1 stathmin 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TACC3 transforming, acidic coiled-coil containing protein 3
TCF3 transcription factor 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI2 tissue factor pathway inhibitor 2
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TKT transketolase
TMPO thymopoietin
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TRIM14 tripartite motif containing 14
TRIP13 thyroid hormone receptor interactor 13
TROAP trophinin associated protein
TYMS thymidylate synthetase
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VGLL1 vestigial-like family member 1
VTCN1 V-set domain containing T cell activation inhibitor 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZNF185 zinc finger protein 185 (LIM domain)
ZWINT ZW10 interacting kinetochore protein