BRD-A24396574_celastrol_A549_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

171 genes differentially expressed following the BRD-A24396574_celastrol_A549_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADIRF adipogenesis regulatory factor
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARMCX1 armadillo repeat containing, X-linked 1
ASPN asporin
ATP11B ATPase, class VI, type 11B
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BGN biglycan
BTG2 BTG family, member 2
C1QA complement component 1, q subcomponent, A chain
C1R complement component 1, r subcomponent
CADM1 cell adhesion molecule 1
CCDC85B coiled-coil domain containing 85B
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL2 chemokine (C-C motif) ligand 2
CCL4 chemokine (C-C motif) ligand 4
CCL8 chemokine (C-C motif) ligand 8
CD9 CD9 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CDV3 CDV3 homolog (mouse)
CHRDL1 chordin-like 1
COL10A1 collagen, type X, alpha 1
COMP cartilage oligomeric matrix protein
CRYAB crystallin, alpha B
CSRP1 cysteine and glycine-rich protein 1
CUX2 cut-like homeobox 2
CXCL13 chemokine (C-X-C motif) ligand 13
CYR61 cysteine-rich, angiogenic inducer, 61
DKK3 dickkopf WNT signaling pathway inhibitor 3
DMD dystrophin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EPHA3 EPH receptor A3
FAM107A family with sequence similarity 107, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FMOD fibromodulin
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FXYD6 FXYD domain containing ion transport regulator 6
GATA2 GATA binding protein 2
GHR growth hormone receptor
GMPR guanosine monophosphate reductase
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
HDAC9 histone deacetylase 9
HIST1H4C histone cluster 1, H4c
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1B interleukin 1, beta
IRF4 interferon regulatory factor 4
KCTD14 potassium channel tetramerization domain containing 14
KRT19 keratin 19, type I
LINC00341 long intergenic non-protein coding RNA 341
LMO3 LIM domain only 3 (rhombotin-like 2)
LMO4 LIM domain only 4
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MFAP5 microfibrillar associated protein 5
MGP matrix Gla protein
MMP12 matrix metallopeptidase 12
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
NUPR1 nuclear protein, transcriptional regulator, 1
OXCT1 3-oxoacid CoA transferase 1
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PDAP1 PDGFA associated protein 1
PDE4A phosphodiesterase 4A, cAMP-specific
PDLIM4 PDZ and LIM domain 4
PEA15 phosphoprotein enriched in astrocytes 15
PID1 phosphotyrosine interaction domain containing 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLK2 polo-like kinase 2
PPIF peptidylprolyl isomerase F
PRELP proline/arginine-rich end leucine-rich repeat protein
PTCH1 patched 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRC protein tyrosine phosphatase, receptor type, C
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBP1 retinol binding protein 1, cellular
RGS5 regulator of G-protein signaling 5
RHOD ras homolog family member D
SAMD4A sterile alpha motif domain containing 4A
SARS seryl-tRNA synthetase
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SST somatostatin
ST7 suppression of tumorigenicity 7
SULF1 sulfatase 1
SYK spleen tyrosine kinase
TACSTD2 tumor-associated calcium signal transducer 2
TF transferrin
TIMP3 TIMP metallopeptidase inhibitor 3
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIM29 tripartite motif containing 29
TSPAN4 tetraspanin 4
UGDH UDP-glucose 6-dehydrogenase
VAMP8 vesicle-associated membrane protein 8
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5 arachidonate 5-lipoxygenase
ASCC3 activating signal cointegrator 1 complex subunit 3
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
CA12 carbonic anhydrase XII
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CCNB2 cyclin B2
CSTA cystatin A (stefin A)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCK deoxycytidine kinase
E2F2 E2F transcription factor 2
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EMP3 epithelial membrane protein 3
ERO1L ERO1-like (S. cerevisiae)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FLNB filamin B, beta
FN1 fibronectin 1
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GPX2 glutathione peroxidase 2
HACD3 3-hydroxyacyl-CoA dehydratase 3
HBB hemoglobin, beta
HEATR1 HEAT repeat containing 1
HOXA10 homeobox A10
HOXC6 homeobox C6
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA2 heat shock 70kDa protein 2
IPO13 importin 13
JADE2 jade family PHD finger 2
LBR lamin B receptor
MAGED1 melanoma antigen family D1
MAP7 microtubule-associated protein 7
MTUS1 microtubule associated tumor suppressor 1
MYO10 myosin X
NRIP1 nuclear receptor interacting protein 1
NTS neurotensin
OPN3 opsin 3
PBK PDZ binding kinase
PCM1 pericentriolar material 1
PIEZO1 piezo-type mechanosensitive ion channel component 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCA protein kinase C, alpha
RNASE4 ribonuclease, RNase A family, 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SPP1 secreted phosphoprotein 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TLR4 toll-like receptor 4
TOX3 TOX high mobility group box family member 3
TSPAN6 tetraspanin 6