BRD-A24396574_celastrol_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

131 genes differentially expressed following the BRD-A24396574_celastrol_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADIRF adipogenesis regulatory factor
ARL4C ADP-ribosylation factor-like 4C
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
C1S complement component 1, s subcomponent
C2CD2 C2 calcium-dependent domain containing 2
CAV1 caveolin 1, caveolae protein, 22kDa
CCL8 chemokine (C-C motif) ligand 8
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL15A1 collagen, type XV, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
CPE carboxypeptidase E
CRISP3 cysteine-rich secretory protein 3
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP1 dual specificity phosphatase 1
EDN1 endothelin 1
EGR1 early growth response 1
FGL2 fibrinogen-like 2
FOS FBJ murine osteosarcoma viral oncogene homolog
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GATAD2A GATA zinc finger domain containing 2A
GJA1 gap junction protein, alpha 1, 43kDa
HMOX1 heme oxygenase 1
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IGFBP3 insulin-like growth factor binding protein 3
JUN jun proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KRT23 keratin 23, type I
LMNB1 lamin B1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MATN2 matrilin 2
MFAP5 microfibrillar associated protein 5
MID1 midline 1
MMP9 matrix metallopeptidase 9
MX1 MX dynamin-like GTPase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRCAM neuronal cell adhesion molecule
NTS neurotensin
PARM1 prostate androgen-regulated mucin-like protein 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLK2 polo-like kinase 2
PLVAP plasmalemma vesicle associated protein
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKCQ protein kinase C, theta
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RND3 Rho family GTPase 3
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SIK1 salt-inducible kinase 1
SLPI secretory leukocyte peptidase inhibitor
SOX17 SRY (sex determining region Y)-box 17
TFPI2 tissue factor pathway inhibitor 2
U2AF1 U2 small nuclear RNA auxiliary factor 1
USP1 ubiquitin specific peptidase 1
VAV3 vav 3 guanine nucleotide exchange factor
VGLL1 vestigial-like family member 1
VWF von Willebrand factor

decreased expression

Symbol Name
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATXN1 ataxin 1
BAD BCL2-associated agonist of cell death
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1
CD52 CD52 molecule
CD59 CD59 molecule, complement regulatory protein
CEMIP cell migration inducing protein, hyaluronan binding
CLDN18 claudin 18
COA3 cytochrome c oxidase assembly factor 3
COMMD8 COMM domain containing 8
COX5B cytochrome c oxidase subunit Vb
COX7B cytochrome c oxidase subunit VIIb
CPD carboxypeptidase D
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DCXR dicarbonyl/L-xylulose reductase
ECI2 enoyl-CoA delta isomerase 2
GCHFR GTP cyclohydrolase I feedback regulator
GSTA4 glutathione S-transferase alpha 4
HEBP1 heme binding protein 1
HNMT histamine N-methyltransferase
HOPX HOP homeobox
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
MAGED1 melanoma antigen family D1
MPG N-methylpurine-DNA glycosylase
MSRB1 methionine sulfoxide reductase B1
NARF nuclear prelamin A recognition factor
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
PFDN5 prefoldin subunit 5
PGC progastricsin (pepsinogen C)
PNKP polynucleotide kinase 3'-phosphatase
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRDX2 peroxiredoxin 2
RBX1 ring-box 1, E3 ubiquitin protein ligase
S100A4 S100 calcium binding protein A4
SCAND1 SCAN domain containing 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPC surfactant protein C
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLIRP SRA stem-loop interacting RNA binding protein
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM100 transmembrane protein 100
TSPAN6 tetraspanin 6
TXNDC9 thioredoxin domain containing 9
UBL5 ubiquitin-like 5
UXT ubiquitously-expressed, prefoldin-like chaperone