BRD-A24396574_celastrol_A375_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

185 genes differentially expressed following the BRD-A24396574_celastrol_A375_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADAMDEC1 ADAM-like, decysin 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
ADRB2 adrenoceptor beta 2, surface
AMPH amphiphysin
ASS1 argininosuccinate synthase 1
BMP2 bone morphogenetic protein 2
BMP4 bone morphogenetic protein 4
C1ORF115 chromosome 1 open reading frame 115
C1R complement component 1, r subcomponent
C3 complement component 3
C6 complement component 6
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCL19 chemokine (C-C motif) ligand 19
CCL5 chemokine (C-C motif) ligand 5
CCR2 chemokine (C-C motif) receptor 2
CD37 CD37 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CES1 carboxylesterase 1
CES2 carboxylesterase 2
CHGB chromogranin B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC10A C-type lectin domain family 10, member A
CLIC5 chloride intracellular channel 5
CLU clusterin
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DNTT DNA nucleotidylexotransferase
EIF5A eukaryotic translation initiation factor 5A
EML1 echinoderm microtubule associated protein like 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FAM129A family with sequence similarity 129, member A
FAM49A family with sequence similarity 49, member A
FGF9 fibroblast growth factor 9
FGL2 fibrinogen-like 2
FOLR1 folate receptor 1 (adult)
FRZB frizzled-related protein
GAS6 growth arrest-specific 6
GHR growth hormone receptor
GIMAP6 GTPase, IMAP family member 6
GJA1 gap junction protein, alpha 1, 43kDa
GPNMB glycoprotein (transmembrane) nmb
GPRASP1 G protein-coupled receptor associated sorting protein 1
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
HDAC9 histone deacetylase 9
IDO1 indoleamine 2,3-dioxygenase 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IL13RA1 interleukin 13 receptor, alpha 1
IL7R interleukin 7 receptor
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD12 potassium channel tetramerization domain containing 12
KCTD14 potassium channel tetramerization domain containing 14
LGALS2 lectin, galactoside-binding, soluble, 2
LYN LYN proto-oncogene, Src family tyrosine kinase
MEF2C myocyte enhancer factor 2C
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MSLN mesothelin
MT1E metallothionein 1E
MT1F metallothionein 1F
MXRA5 matrix-remodelling associated 5
NAP1L2 nucleosome assembly protein 1-like 2
NELL2 NEL-like 2 (chicken)
NMU neuromedin U
NOV nephroblastoma overexpressed
NPR1 natriuretic peptide receptor 1
NRCAM neuronal cell adhesion molecule
NUAK1 NUAK family, SNF1-like kinase, 1
OLFM1 olfactomedin 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCP4 Purkinje cell protein 4
PERP PERP, TP53 apoptosis effector
PHACTR2 phosphatase and actin regulator 2
PID1 phosphotyrosine interaction domain containing 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PODXL podocalyxin-like
PPL periplakin
PRKX protein kinase, X-linked
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRC protein tyrosine phosphatase, receptor type, C
RAB2A RAB2A, member RAS oncogene family
REG1A regenerating islet-derived 1 alpha
RPL37A ribosomal protein L37a
RTN1 reticulon 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SAMHD1 SAM domain and HD domain 1
SCD5 stearoyl-CoA desaturase 5
SCGB2A1 secretoglobin, family 2A, member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A1 solute carrier family 38, member 1
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOX17 SRY (sex determining region Y)-box 17
SST somatostatin
STC1 stanniocalcin 1
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
SYT1 synaptotagmin I
TAPBPL TAP binding protein-like
TCEAL2 transcription elongation factor A (SII)-like 2
TEK TEK tyrosine kinase, endothelial
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TLK2 tousled-like kinase 2
TMPRSS3 transmembrane protease, serine 3
TPMT thiopurine S-methyltransferase
TPPP3 tubulin polymerization-promoting protein family member 3
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIM36 tripartite motif containing 36
TXNIP thioredoxin interacting protein
VAV3 vav 3 guanine nucleotide exchange factor
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VSNL1 visinin-like 1
WNK1 WNK lysine deficient protein kinase 1

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ACSL3 acyl-CoA synthetase long-chain family member 3
ADAM10 ADAM metallopeptidase domain 10
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BZW1 basic leucine zipper and W2 domains 1
CD59 CD59 molecule, complement regulatory protein
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHSY1 chondroitin sulfate synthase 1
CLTC clathrin, heavy chain (Hc)
CXCL8 chemokine (C-X-C motif) ligand 8
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
ETNK1 ethanolamine kinase 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FXYD3 FXYD domain containing ion transport regulator 3
HES1 hes family bHLH transcription factor 1
HNMT histamine N-methyltransferase
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP4 insulin-like growth factor binding protein 4
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KLHL9 kelch-like family member 9
LTF lactotransferrin
LYPLA1 lysophospholipase I
MSMO1 methylsterol monooxygenase 1
MYLK myosin light chain kinase
NES nestin
OAT ornithine aminotransferase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKM pyruvate kinase, muscle
PLAT plasminogen activator, tissue
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RPA3 replication protein A3, 14kDa
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC16A4 solute carrier family 16, member 4
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TRIB2 tribbles pseudokinase 2
TSPAN13 tetraspanin 13
UBE2E1 ubiquitin-conjugating enzyme E2E 1
VAT1 vesicle amine transport 1
WWTR1 WW domain containing transcription regulator 1
YME1L1 YME1-like 1 ATPase
ZDHHC6 zinc finger, DHHC-type containing 6