BRD-A24191444_Ifenprodil tartrate_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

183 genes differentially expressed following the BRD-A24191444_Ifenprodil tartrate_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACLY ATP citrate lyase
AKAP12 A kinase (PRKA) anchor protein 12
CALR calreticulin
CAPN2 calpain 2, (m/II) large subunit
COL6A2 collagen, type VI, alpha 2
CST6 cystatin E/M
F13A1 coagulation factor XIII, A1 polypeptide
FCGBP Fc fragment of IgG binding protein
FST follistatin
GAL galanin/GMAP prepropeptide
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GUSBP11 glucuronidase, beta pseudogene 11
HOMER3 homer scaffolding protein 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IL1RN interleukin 1 receptor antagonist
KDM7A lysine (K)-specific demethylase 7A
KLK5 kallikrein-related peptidase 5
LGALS1 lectin, galactoside-binding, soluble, 1
LOC100286895 cell division cycle 27 homolog pseudogene
MAOA monoamine oxidase A
MMP11 matrix metallopeptidase 11
PERP PERP, TP53 apoptosis effector
PLAU plasminogen activator, urokinase
PRSS3 protease, serine, 3
RAB2A RAB2A, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SCGB1D2 secretoglobin, family 1D, member 2
SHB Src homology 2 domain containing adaptor protein B
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOX9 SRY (sex determining region Y)-box 9
SPRR3 small proline-rich protein 3
SRSF5 serine/arginine-rich splicing factor 5
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AGO3 argonaute RISC catalytic component 3
AMD1 adenosylmethionine decarboxylase 1
ANKRD36B ankyrin repeat domain 36B
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARL1 ADP-ribosylation factor-like 1
ARMCX3 armadillo repeat containing, X-linked 3
ARMT1 acidic residue methyltransferase 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BST2 bone marrow stromal cell antigen 2
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CCNG1 cyclin G1
CDK4 cyclin-dependent kinase 4
CDKN3 cyclin-dependent kinase inhibitor 3
CHL1 cell adhesion molecule L1-like
CLIC5 chloride intracellular channel 5
CLINT1 clathrin interactor 1
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa
CXCL5 chemokine (C-X-C motif) ligand 5
CYFIP2 cytoplasmic FMR1 interacting protein 2
DARS aspartyl-tRNA synthetase
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DLD dihydrolipoamide dehydrogenase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DPY19L4 dpy-19-like 4 (C. elegans)
EBNA1BP2 EBNA1 binding protein 2
EED embryonic ectoderm development
EGR3 early growth response 3
EIF5B eukaryotic translation initiation factor 5B
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM134B family with sequence similarity 134, member B
FKBP3 FK506 binding protein 3, 25kDa
G0S2 G0/G1 switch 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GCH1 GTP cyclohydrolase 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GOLT1B golgi transport 1B
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
GRB14 growth factor receptor-bound protein 14
HACD2 3-hydroxyacyl-CoA dehydratase 2
HEXIM1 hexamethylene bis-acetamide inducible 1
HIBCH 3-hydroxyisobutyryl-CoA hydrolase
HIPK1 homeodomain interacting protein kinase 1
HLTF helicase-like transcription factor
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
KIAA0101 KIAA0101
KIAA0368 KIAA0368
KIF2C kinesin family member 2C
KYNU kynureninase
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LXN latexin
LY75 lymphocyte antigen 75
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MARCKS myristoylated alanine-rich protein kinase C substrate
MET MET proto-oncogene, receptor tyrosine kinase
MOAP1 modulator of apoptosis 1
MPZL1 myelin protein zero-like 1
MRPS30 mitochondrial ribosomal protein S30
MSH6 mutS homolog 6
MTDH metadherin
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC1 mucin 1, cell surface associated
MYH10 myosin, heavy chain 10, non-muscle
NAV2 neuron navigator 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NKTR natural killer cell triggering receptor
NPC1 Niemann-Pick disease, type C1
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
OXTR oxytocin receptor
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCNA proliferating cell nuclear antigen
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRPF4 pre-mRNA processing factor 4
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PUS7 pseudouridylate synthase 7 (putative)
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
REEP5 receptor accessory protein 5
RFK riboflavin kinase
RPS27L ribosomal protein S27-like
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RRP1B ribosomal RNA processing 1B
SACS sacsin molecular chaperone
SAMD4A sterile alpha motif domain containing 4A
SEPP1 selenoprotein P, plasma, 1
SF1 splicing factor 1
SIK1 salt-inducible kinase 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC25A46 solute carrier family 25, member 46
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMS spermine synthase
SOD2 superoxide dismutase 2, mitochondrial
SRSF11 serine/arginine-rich splicing factor 11
STK17B serine/threonine kinase 17b
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TARBP1 TAR (HIV-1) RNA binding protein 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TFAM transcription factor A, mitochondrial
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIGAR TP53 induced glycolysis regulatory phosphatase
TM4SF1 transmembrane 4 L six family member 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM22 tripartite motif containing 22
TSNAX translin-associated factor X
TSPAN13 tetraspanin 13
TSPAN31 tetraspanin 31
TSPYL1 TSPY-like 1
TSPYL5 TSPY-like 5
TYMS thymidylate synthetase
UBE2G2 ubiquitin-conjugating enzyme E2G 2
USP1 ubiquitin specific peptidase 1
USP33 ubiquitin specific peptidase 33
WFDC2 WAP four-disulfide core domain 2
WRB tryptophan rich basic protein
XPO1 exportin 1
ZBTB10 zinc finger and BTB domain containing 10
ZMAT3 zinc finger, matrin-type 3
ZMYM2 zinc finger, MYM-type 2
ZMYND8 zinc finger, MYND-type containing 8
ZNF131 zinc finger protein 131