BRD-A24054354_-666_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-A24054354_-666_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AK4 adenylate kinase 4
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CAST calpastatin
CD14 CD14 molecule
CD163 CD163 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CSF3R colony stimulating factor 3 receptor (granulocyte)
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FPR1 formyl peptide receptor 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
HBB hemoglobin, beta
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IL6ST interleukin 6 signal transducer
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MNDA myeloid cell nuclear differentiation antigen
MPO myeloperoxidase
MUC4 mucin 4, cell surface associated
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NRCAM neuronal cell adhesion molecule
NRN1 neuritin 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
RAB32 RAB32, member RAS oncogene family
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100A12 S100 calcium binding protein A12
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SOD2 superoxide dismutase 2, mitochondrial
SQSTM1 sequestosome 1
TICAM1 toll-like receptor adaptor molecule 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
AIM1 absent in melanoma 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
C7 complement component 7
CTSH cathepsin H
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DUSP6 dual specificity phosphatase 6
GPRC5B G protein-coupled receptor, class C, group 5, member B
GREM1 gremlin 1, DAN family BMP antagonist
H2BFS H2B histone family, member S (pseudogene)
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IPO13 importin 13
ISG15 ISG15 ubiquitin-like modifier
LAMP5 lysosomal-associated membrane protein family, member 5
LGALS1 lectin, galactoside-binding, soluble, 1
MDK midkine (neurite growth-promoting factor 2)
NES nestin
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PRSS2 protease, serine, 2 (trypsin 2)
PTGIS prostaglandin I2 (prostacyclin) synthase
SMYD3 SET and MYND domain containing 3
SPINK1 serine peptidase inhibitor, Kazal type 1
SPP1 secreted phosphoprotein 1