BRD-A24054354_-666_SW620_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

153 genes differentially expressed following the BRD-A24054354_-666_SW620_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ADM adrenomedullin
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZU1 azurocidin 1
BHLHE40 basic helix-loop-helix family, member e40
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CALR calreticulin
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD69 CD69 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CTSE cathepsin E
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EGR1 early growth response 1
EGR3 early growth response 3
EIF1 eukaryotic translation initiation factor 1
ELANE elastase, neutrophil expressed
EREG epiregulin
ESR1 estrogen receptor 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
LAMA3 laminin, alpha 3
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
OLFML2A olfactomedin-like 2A
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRTN3 proteinase 3
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RHOB ras homolog family member B
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SCGB1D2 secretoglobin, family 1D, member 2
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SHB Src homology 2 domain containing adaptor protein B
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SRRM2 serine/arginine repetitive matrix 2
STC2 stanniocalcin 2
TFF3 trefoil factor 3 (intestinal)
TFRC transferrin receptor
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADI1 acireductone dioxygenase 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATMIN ATM interactor
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
C3 complement component 3
CCL19 chemokine (C-C motif) ligand 19
CCNB2 cyclin B2
CCNF cyclin F
CDK4 cyclin-dependent kinase 4
CENPA centromere protein A
CFH complement factor H
CTSC cathepsin C
CXCL14 chemokine (C-X-C motif) ligand 14
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLD dihydrolipoamide dehydrogenase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EBNA1BP2 EBNA1 binding protein 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FOLR1 folate receptor 1 (adult)
HMGA2 high mobility group AT-hook 2
HOXC6 homeobox C6
IGFBP7 insulin-like growth factor binding protein 7
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LAMB1 laminin, beta 1
LAMP5 lysosomal-associated membrane protein family, member 5
LAPTM4B lysosomal protein transmembrane 4 beta
LXN latexin
LY75 lymphocyte antigen 75
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MYCBP MYC binding protein
MYH11 myosin, heavy chain 11, smooth muscle
NEFH neurofilament, heavy polypeptide
NME4 NME/NM23 nucleoside diphosphate kinase 4
NT5DC2 5'-nucleotidase domain containing 2
PAM peptidylglycine alpha-amidating monooxygenase
PCP4 Purkinje cell protein 4
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLK1 polo-like kinase 1
PLTP phospholipid transfer protein
PNMAL1 paraneoplastic Ma antigen family-like 1
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROM1 prominin 1
PRPF4 pre-mRNA processing factor 4
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM47 RNA binding motif protein 47
S100A13 S100 calcium binding protein A13
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SORBS3 sorbin and SH3 domain containing 3
STOM stomatin
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMX4 thioredoxin-related transmembrane protein 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN13 tetraspanin 13
TWF1 twinfilin actin binding protein 1
TXNDC9 thioredoxin domain containing 9
UBL3 ubiquitin-like 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UNC119B unc-119 homolog B (C. elegans)
WFDC2 WAP four-disulfide core domain 2
ZNF318 zinc finger protein 318