BRD-A24021119_NCGC00183696-01_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

253 genes differentially expressed following the BRD-A24021119_NCGC00183696-01_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AGR2 anterior gradient 2
ALDOC aldolase C, fructose-bisphosphate
ANXA1 annexin A1
AREG amphiregulin
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ARMCX1 armadillo repeat containing, X-linked 1
ASPN asporin
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AUTS2 autism susceptibility candidate 2
BEX1 brain expressed, X-linked 1
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BTG3 BTG family, member 3
CA4 carbonic anhydrase IV
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CCDC92 coiled-coil domain containing 92
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CERS6 ceramide synthase 6
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLIC4 chloride intracellular channel 4
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
COMP cartilage oligomeric matrix protein
CPA3 carboxypeptidase A3 (mast cell)
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT4 DNA-damage-inducible transcript 4
DENND5A DENN/MADD domain containing 5A
DESI2 desumoylating isopeptidase 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPT dermatopontin
EFHD1 EF-hand domain family, member D1
EGFR epidermal growth factor receptor
EGLN3 egl-9 family hypoxia-inducible factor 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPYC epiphycan
ERBB4 erb-b2 receptor tyrosine kinase 4
F11R F11 receptor
FAM129A family with sequence similarity 129, member A
FAM46A family with sequence similarity 46, member A
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FOXO3 forkhead box O3
GABARAPL1 GABA(A) receptor-associated protein like 1
GAS7 growth arrest-specific 7
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GPC4 glypican 4
GPNMB glycoprotein (transmembrane) nmb
GSN gelsolin
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA13 heat shock protein 70kDa family, member 13
HSPB8 heat shock 22kDa protein 8
IGFBP7 insulin-like growth factor binding protein 7
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IL32 interleukin 32
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KLF10 Kruppel-like factor 10
LEFTY1 left-right determination factor 1
LRP4 low density lipoprotein receptor-related protein 4
LRRC15 leucine rich repeat containing 15
LTF lactotransferrin
LYZ lysozyme
MAPT microtubule-associated protein tau
MFAP5 microfibrillar associated protein 5
MGP matrix Gla protein
MMP10 matrix metallopeptidase 10
MMP7 matrix metallopeptidase 7
MPZL2 myelin protein zero-like 2
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MXRA5 matrix-remodelling associated 5
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUAK1 NUAK family, SNF1-like kinase, 1
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM1 olfactomedin 1
OMD osteomodulin
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PADI2 peptidyl arginine deiminase, type II
PDE4DIP phosphodiesterase 4D interacting protein
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGK1 phosphoglycerate kinase 1
PLN phospholamban
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTN pleiotrophin
QKI QKI, KH domain containing, RNA binding
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS1 regulator of G-protein signaling 1
RGS13 regulator of G-protein signaling 13
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SELE selectin E
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD7 SMAD family member 7
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SST somatostatin
STK38L serine/threonine kinase 38 like
SULF1 sulfatase 1
SYBU syntabulin (syntaxin-interacting)
TF transferrin
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM2 transmembrane protein 2
TMEM47 transmembrane protein 47
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOX3 TOX high mobility group box family member 3
TPSAB1 tryptase alpha/beta 1
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
UGP2 UDP-glucose pyrophosphorylase 2
VCAN versican
XBP1 X-box binding protein 1
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ALDOB aldolase B, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
APEH acylaminoacyl-peptide hydrolase
APRT adenine phosphoribosyltransferase
ATF5 activating transcription factor 5
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
B3GNT1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BOP1 block of proliferation 1
CA12 carbonic anhydrase XII
CBR1 carbonyl reductase 1
CD47 CD47 molecule
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDKN3 cyclin-dependent kinase inhibitor 3
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKS2 CDC28 protein kinase regulatory subunit 2
CLGN calmegin
COA3 cytochrome c oxidase assembly factor 3
CTPS1 CTP synthase 1
DCTD dCMP deaminase
DCXR dicarbonyl/L-xylulose reductase
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DEFB1 defensin, beta 1
DHRS1 dehydrogenase/reductase (SDR family) member 1
DKC1 dyskeratosis congenita 1, dyskerin
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DPYD dihydropyrimidine dehydrogenase
EIF4E eukaryotic translation initiation factor 4E
EML3 echinoderm microtubule associated protein like 3
F12 coagulation factor XII (Hageman factor)
FJX1 four jointed box 1 (Drosophila)
GNG12 guanine nucleotide binding protein (G protein), gamma 12
H2BFS H2B histone family, member S (pseudogene)
HIST1H2BK histone cluster 1, H2bk
HMGA1 high mobility group AT-hook 1
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ISOC2 isochorismatase domain containing 2
JADE2 jade family PHD finger 2
KIAA0100 KIAA0100
KIF20A kinesin family member 20A
KRT10 keratin 10, type I
LY6D lymphocyte antigen 6 complex, locus D
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK13 mitogen-activated protein kinase 13
MICALL1 MICAL-like 1
MRPL12 mitochondrial ribosomal protein L12
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NHP2 NHP2 ribonucleoprotein
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME3 NME/NM23 nucleoside diphosphate kinase 3
NOP56 NOP56 ribonucleoprotein
NQO1 NAD(P)H dehydrogenase, quinone 1
NUP210 nucleoporin 210kDa
NUTF2 nuclear transport factor 2
PFKM phosphofructokinase, muscle
PNKP polynucleotide kinase 3'-phosphatase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPA2 pyrophosphatase (inorganic) 2
PRMT1 protein arginine methyltransferase 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPP25 ribonuclease P/MRP 25kDa subunit
RPP40 ribonuclease P/MRP 40kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUVBL1 RuvB-like AAA ATPase 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SLIRP SRA stem-loop interacting RNA binding protein
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SRM spermidine synthase
SRSF6 serine/arginine-rich splicing factor 6
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TARBP1 TAR (HIV-1) RNA binding protein 1
TDO2 tryptophan 2,3-dioxygenase
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TRIM14 tripartite motif containing 14
TRIP6 thyroid hormone receptor interactor 6
TUSC3 tumor suppressor candidate 3
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
WDR12 WD repeat domain 12
WNT5A wingless-type MMTV integration site family, member 5A