BRD-A24021119_NCGC00183696-01_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-A24021119_NCGC00183696-01_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADM adrenomedullin
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
ARG2 arginase 2
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CADM1 cell adhesion molecule 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL11A1 collagen, type XI, alpha 1
CRYAB crystallin, alpha B
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DPYSL3 dihydropyrimidinase-like 3
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
FABP4 fatty acid binding protein 4, adipocyte
FHL1 four and a half LIM domains 1
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GPX3 glutathione peroxidase 3
HILPDA hypoxia inducible lipid droplet-associated
HMOX1 heme oxygenase 1
IGF1R insulin-like growth factor 1 receptor
JUN jun proto-oncogene
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
LPL lipoprotein lipase
LRRC17 leucine rich repeat containing 17
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
METTL7A methyltransferase like 7A
MT1F metallothionein 1F
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PTX3 pentraxin 3, long
RAP1GAP RAP1 GTPase activating protein
RGS1 regulator of G-protein signaling 1
SESN1 sestrin 1
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPX sushi-repeat containing protein, X-linked
STK10 serine/threonine kinase 10
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TP53 tumor protein p53
ZBTB16 zinc finger and BTB domain containing 16

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMD1 adenosylmethionine decarboxylase 1
AQP3 aquaporin 3 (Gill blood group)
CA12 carbonic anhydrase XII
CDC25A cell division cycle 25A
CLCA2 chloride channel accessory 2
FASTKD5 FAST kinase domains 5
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
HOPX HOP homeobox
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KRT6A keratin 6A, type II
LEF1 lymphoid enhancer-binding factor 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LYZ lysozyme
MAP7 microtubule-associated protein 7
NT5DC2 5'-nucleotidase domain containing 2
PI3 peptidase inhibitor 3, skin-derived
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
RAB25 RAB25, member RAS oncogene family
RRM2 ribonucleotide reductase M2
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
TACSTD2 tumor-associated calcium signal transducer 2
TFF1 trefoil factor 1
TM4SF1 transmembrane 4 L six family member 1
TPD52L1 tumor protein D52-like 1
TRIB2 tribbles pseudokinase 2
WSB2 WD repeat and SOCS box containing 2
XBP1 X-box binding protein 1